Duke Miglin is the son of noted Chicago real estate developer Lee Miglin, who was murdered by serial killer Andrew Cunanan, who later shot and killed famed fashion designer Gianni Versace. Duke's mother, Marilyn Miglin, is the founder and president of Marilyn Miglin Cosmetics. Lee and Marilyn, along with Duke, were all central characters in the third episode of the FX limited series, American Crime Story: The Assassination of Gianni Versace.