- After dubbing Jack Nicholson's voice in the Italian version of The Shining (1980), he received a telegram of congratulations from Stanley Kubrick.
- His great passion is inventing. Among other things, he invented the moving, playing jacket Robin Williams was wearing in Toys (1992).
- Italian dubbing voice of Jack Nicholson, Al Pacino, Michael Douglas, Gérard Depardieu, Dustin Hoffman and Ryan O'Neal.
- He was awarded a Star on the Hollywood Fame at 6361 Hollywood Boulevard in Hollywood, California on March 6, 2023.
- In 2003, he was christened Grand Officer of the Order of Merit of the Italian Republic, Italy's highest civilian honor, for his services to the arts. In 2007, he was re-christened Knight Grand Cross of the Order of Merit of the Italian Republic.
- Has two sons with Livia Giampalmo: Lorenzo Giannini (1967-1987) and actor Adriano Giannini (born 1971). Has two sons with Eurilla del Bono: Emanuele Giannini and Francesco Giannini.
- Has played a police officer for both director Ridley Scott (Hannibal (2001)) and his brother Tony Scott (Man on Fire (2004)).
- Was among those offered for the role of Indiana Jones' archenemy Rene Belloq in Raiders of the Lost Ark (1981), which went to Paul Freeman.
- He was awarded a star on the Italian Walk of Fame in Toronto, Ontario in 2009.
- Fluent in Italian, English, French and Spanish.
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