Francesca Annis nació el 14 de mayo de 1945 en Kensington, Londres, Inglaterra. Es una actriz, conocida por Dunas (1984), Krull (1983) y Lillie (1978).
Former long-term companion was British actor Ralph Fiennes (El paciente inglés (1996)). They meet while performing the play "Hamlet" in 1994. She portrayed Gertrude, he played Hamlet. The couple broke up in February 2006.