Supervillains Harley Quinn, Bloodsport, Peacemaker, and a collection of nutty cons at Belle Reve prison join the super-secret, super-shady Task Force X as they are dropped off at the remote, enemy-infused island of Corto Maltese.
A deadly threat from Earth's history reappears and a hunt for a lost artifact takes place between Autobots and Decepticons, while Optimus Prime encounters his creator in space.