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- DirectorBryan SingerStarsHugh LaurieLisa EdelsteinOmar EppsYoung kindergarten teacher Rebecca Adler collapses in her classroom after losing intelligible speech while teaching students.
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsThe team helps a high school boy (16) who has double vision and night terrors. (Clinic Cases: Unvaccinated baby, man with boil on leg.)
- DirectorBryan SingerStarsHugh LaurieLisa EdelsteinOmar EppsA college boy whose low blood pressure does not respond with IV fluids piques House's curiosity. Clinic Cases: A woman who had a cold last week, man with a sore throat, woman whose leg hurts after running 6 miles, a boy and his MP3 Player.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA nightmare scenario hits Princeton Plainsboro when babies in the maternity ward are hit by a potentially fatal epidemic. Clinic Cases: Woman with a parasite!
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsA nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- DirectorPeter MedakStarsHugh LaurieLisa EdelsteinOmar EppsA 38-year-old mother, apparently suffering from thrombosis, alcoholism and schizophrenia, has only her young son as caregiver.
- 2012–201629mTV-MA7.8 (154)TV EpisodeDirectorMatthew CarnahanStarsDon CheadleKristen BellBen SchwartzMarty is on the verge of making K&A one of the biggest players in the business, if he can persuade his employees to stay. Jeannie gives birth. Clyde, Doug, and Kelsey await an offer - and Roscoe faces the consequences. Season finale.
- DirectorMatthew CarnahanStarsDon CheadleKristen BellBen SchwartzMarty and Jeannie navigate the hazards of co-parenting. Doug and Clyde maneuver for position. A familiar face from the past approaches Marty with an intriguing offer. Season premiere.
- DirectorDon CheadleStarsDon CheadleKristen BellBen SchwartzJeannie's boyfriend drops a bomb that could devastate her. Marty goes after potential new business at Doug's "Dungeons and Dragons" game. Clyde uncovers an issue that affects Jeannie.
- DirectorBryan SpicerStarsHugh LaurieLisa EdelsteinOmar EppsA woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- DirectorGuy FerlandStarsHugh LaurieLisa EdelsteinOmar EppsA high school boy has hallucinations and collapses during an exam. When he does not respond to treatments, and the normal tests are negative, Foreman presents the case to House. Clinic Cases: A happy old lady.
- DirectorDaisy von Scherler MayerStarsDon CheadleKristen BellBen SchwartzWith Jeannie back at K&A, Marty and the Pod consult for a new company trying an unconventional management style. Doug wonders if there is a possibility of K&A's newest client and Clyde has an ill-timed breakup.
- DirectorFrederick King KellerStarsHugh LaurieLisa EdelsteinOmar EppsA famous jazz trumpeter, diagnosed with ALS, signs a DNR form, but because House believes the diagnosis wrong, he breaks the law by resuscitating him.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsA delusional homeless woman is found unconscious in an acid house exhibiting a variety of symptoms which Foreman thinks she's faking.
- DirectorDaisy von Scherler MayerStarsDon CheadleKristen BellBen SchwartzWhile competing with Monica for business, Marty learns she's been offered a lucrative deal. Jeannie romances a client with a questionable past. Clyde is tapped for a new venture and Doug obsesses over the chance to give a TED Talk.
- DirectorGary B. GoldmanStarsDon CheadleKristen BellBen SchwartzMarty begrudgingly reunites with a pair of his most obnoxious past clients to expand the business of a major cruise line. Meanwhile, Clyde gets in the way of Doug's high-seas fantasy and Jeannie gets emotional over the baby.
- DirectorNelson McCormickStarsHugh LaurieLisa EdelsteinOmar EppsA girl crashes a Porsche after her boyfriend starts coughing up blood and continues to have unexplained bleeds. Clinic Cases: Cuddy gives House a month off clinic duties if he can spend a week off his pain meds.
- DirectorDon CheadleStarsDon CheadleKristen BellBen SchwartzMarty's entrée into the black-hair market on the behalf of a client hits a surprising snag; Clyde's great hope for mayor has eyes for Jeannie; Roscoe lands his first modeling gig.
- DirectorKeith GordonStarsHugh LaurieLisa EdelsteinOmar EppsA detoxed sports star about to make his comeback breaks his arm due to brittle bones. Clinic Cases: Woman with leg pain, man trying to remove his contact lenses, a dentist with various issues, and a hung over teenager - all in 70 seconds.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe first shift for new surgical interns Meredith, Cristina, Izzie, George, and Alex proves eventful and backbreaking.
- 2014–2017TV Episode
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglA rape victim is admitted, who managed to hold onto part of her attacker; Izzie has difficulty with a patient who cannot speak English; Meredith becomes concerned about a sick baby.
- DirectorTony GoldwynStarsEllen PompeoSandra OhKatherine HeiglIzzie and Cristina are assigned a close-to-brain-dead John Doe who may be a viable candidate for organ donation, and helpful to George's patient, who needs a new liver. Meanwhile, Meredith and Alex butt heads over a patient of their own.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglAlex uses Izzie's modeling against her, and her last ad causes a patient to reject her care. Meredith finds parallels between a patient and her mother, and Christina must deal with a hospital-savvy patient.
- DirectorJohn David ColesStarsEllen PompeoSandra OhKatherine HeiglMeredith worries she did something wrong during a heart bypass, an error in a past procedure is discovered, putting a staff member's conduct under scrutiny, while a party thrown by Izzie to introduce her boyfriend becomes a fiasco.
- DirectorScott BrazilStarsEllen PompeoSandra OhKatherine HeiglA woman with a massive tumor is admitted, with all the surgeons required to scrub in. In their absence, Meredith is assigned a patient with Parkinson's and, because Alex's pager is not working, Izzie is left in charge of the floor herself.
- DirectorDarnell MartinStarsEllen PompeoSandra OhKatherine HeiglIzzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
- DirectorSarah Pia AndersonStarsEllen PompeoSandra OhKatherine HeiglMeredith wants to learn more about Derek, but he remains cagey. Meanwhile, a supposedly psychic patient proves bothersome, Alex must convince a young girl to agree to a life saving operation, and Cristina is conflicted about her pregnancy.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglGeorge finally gets laid but gets syphilis. It's rampant among staff. Surgeon Webber is losing his sight. He wants Shepherd to operate secretly. A male patient has an ovary. A lifesaving autopsy's performed without consent.
- 2005– 43mTV-148.3 (1.7K)TV EpisodeDirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglMeredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglA family is admitted after being involved in a car crash, but there is more to them than meets the eye. Meanwhile, Bailey and her team deal with a strange case, and relationship woes plague Meredith, Cristina and George.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglMeredith is horrified when her mother is admitted, and everyone is concerned when Cristina collapses in the operating room. Meanwhile, Addison is determined to save a very sick baby.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglCristina is determined to get back to work, and despite not being fully recovered, she manages to crack an odd case. Meanwhile, Addison offers to help Bailey with a complicated surgery, and Alex receives important news.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglA storm rages, causing power outages and jamming the elevator, trapping George and Alex inside with a vulnerable patient. Meanwhile, Meredith and Derek arrange a religious ritual for a young woman, and Cristina deals with an unusual case.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglA train wreck brings in multiple casualties, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his mojo a disheartening experience, and Cristina searches high and low for a missing appendage.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglDerek reluctantly attends marriage counseling with Addison, while Meredith, Izzie and Cristina steal a patient with an unusual problem. Alex helps a young patient gain her independence, and Cristina thinks Bailey knows about her and Burke.
- DirectorLesli Linka GlatterStarsEllen PompeoSandra OhKatherine HeiglFriends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.
- DirectorMichael DinnerStarsEllen PompeoSandra OhKatherine HeiglThanksgiving sends the occupants of Meredith's house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner to which it appears no one is coming.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglMeredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe mother of the quints blames herself. Meanwhile, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina takes care of an inmate desperate to stay at the hospital.
- 2005– 1hTV-148.1 (1.4K)TV EpisodeDirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglChristmas hits Seattle, with Izzie caring for a man who fell from his roof while hanging decorations. Meanwhile, Cristina helps perform a heart transplant on a depressed boy, and George has to contend with the family from Hell.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglIzzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglMeredith must choose between her dog and her roommates. Meanwhile, George deals with an elderly patient who has outstayed her welcome, Bailey's pregnancy has complications, Alex gets his exam results, and Richard has a strike on his hands.
- DirectorDavid PaymerStarsEllen PompeoSandra OhKatherine HeiglThe nurses are striking, and George refuses to cross the picket line. The interns are surprised by Bailey's seemingly immature replacement, Izzie connects with a pregnant girl, and an elderly woman's plight pushes Meredith to the limit.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe lives of everyone in the OR are threatened when a patient enters with a bomb inside him, and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglWhile the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglDerek and Addison are shaken by the arrival of a figure from their past. Meanwhile, Burke learns Cristina's secret, Izzie deals with a very unusual case, Meredith delves into her family's dirty laundry, and George pours his heart out.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglMeredith and George face the consequences of their actions, Izzie gets closer to Denny, who has been readmitted, and Addison asks for Bailey's help with an embarrassing ailment.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglCristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.
- DirectorTricia BrockStarsEllen PompeoSandra OhKatherine HeiglSuperstition strikes, with the interns convinced a series of deaths will occur. A complication from the LVAD surgery puts Denny in the OR, Cristina plans to make George move out, and Richard's old AA sponsor is admitted for treatment.
- DirectorSeith MannStarsEllen PompeoSandra OhKatherine HeiglCristina is desperate for George to move out of the apartment, while Izzie is jealous of Callie's relationship with him. Meanwhile, Cristina and Richard are rivals in a surgery seminar, and Meredith discovers a secret about her father.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglMeredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
- DirectorTony GoldwynStarsEllen PompeoSandra OhKatherine HeiglThe victims of a serious car accident are admitted, with every surgeon required to help. Meanwhile, Callie's forwardness grates on Izzie, Addison makes Alex suffer, and Derek takes his frustration out on Meredith.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe victims of a workplace shooting are admitted. Izzie puts her job on the line to ensure Denny gets a new heart, Callie makes an effort with Meredith, and Addison is suspicious of Derek.
- 2005– 1hTV-149.0 (1.9K)TV EpisodeDirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglBurke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglRichard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglEveryone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglIzzie copes with her grief by baking furiously, and George has to deal with an obstinate patient. Meanwhile, Meredith must choose between Derek and Finn, Addison drowns her sorrows in alcohol, and Cristina meets Burke's difficult mother.
- DirectorAdam ArkinStarsEllen PompeoSandra OhKatherine HeiglIzzie returns to the hospital, but finds it difficult to go inside, and George is tired of Callie's presence at home. Meanwhile, Addison cannot seem to get rid of Mark, and Cristina tries to cope with caring for Burke.
- DirectorDan LernerStarsEllen PompeoSandra OhKatherine HeiglMeredith becomes a patient, and Derek and Addison are equally angry at Richard for allowing Mark to join the staff. Meanwhile, Izzie receives a visit from Denny's father, and Burke is plagued by doubt over his ability to return to surgery.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglGuilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglIzzie returns to the hospital under probation, and George tries to make amends with Callie. Meanwhile, Cristina's deletion of Bailey's name on Burke's OR board makes her assume he is against her, and Derek's irritating sister Nancy visits.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglDerek, George, Alex, Burke, Richard, Joe and Walter go on a camping trip. Meanwhile, Meredith assists Mark with gender reassignment surgery, Izzie avoids discussing her grief, Addison works with Callie, and Cristina feels Bailey's wrath.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglGeorge must deal with his family's presence when his father is admitted. Meanwhile, Burke's secret is almost out, Alex tries to get close to Izzie again, and Richard comes to a decision about his marriage.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglA traumatic car accident fills the ER. Cristina has a crisis of conscience about her deceptive teamwork with Burke, Izzie pushes the boundaries of her probation, and Callie tries to explain herself to George.
- DirectorSeith MannStarsEllen PompeoSandra OhKatherine HeiglBailey is adamant that Burke and Cristina should be punished, Derek doubts his abilities, Izzie tries to take a stand against Mark's patronizing behavior, and Meredith deals with family in two very different ways.
- DirectorGreg YaitanesStarsEllen PompeoSandra OhKatherine HeiglAs George's father's surgery approaches, he begins to realize how serious his condition is. Meanwhile, Izzie has to prove to Bailey that she is ready to scrub in on a surgery, and Meredith keeps running into her father.
- DirectorGreg YaitanesStarsEllen PompeoSandra OhKatherine HeiglGeorge's father's surgery has left him very weak, Izzie's act of generosity backfires on her, Cristina and Burke continue their war of silence, and Meredith reaches out to her father.
- DirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglGeorge deals with his grief, Cristina and Burke continue to ignore each other, Addison avoids Alex, and Izzie decides to help Bailey with a project. Meanwhile, Richard makes a decision which sends all the attendings scrambling.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglA toxic patient wreaks havoc. Meanwhile, Bailey opens the free clinic, but the lack of patients makes Izzie question her investment. Meredith's mother is admitted again, and Cristina makes Burke wait for an answer.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe interns each react differently to a mass-casualty incident. Meanwhile, George crosses the professional line with Callie, Cristina asks Burke to keep quiet about their engagement, and Richard dons a new hairstyle.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglIzzie fights to save her patient's life, George searches for the son of his patient, and Alex has to contend with the relatives of victims. Meanwhile, Meredith is unconscious underwater, with Derek her only hope.
- DirectorAdam ArkinStarsEllen PompeoSandra OhKatherine HeiglAn unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglA Korean war veteran with a bullet lodged in his shoulder is admitted. Meanwhile, tensions escalate between Izzie and George, Callie reveals a big secret, Cristina contends with an old flame, and Alex continues to work with the Jane Doe.
- DirectorTamra DavisStarsEllen PompeoSandra OhKatherine HeiglThe attendings face their board interviews. Meanwhile, Izzie seems to be the only one who remembers the night before, Derek is overly protective of Meredith when Mark offers her a surgery, and Callie's father pays a visit.
- DirectorChristopher MisianoStarsEllen PompeoSandra OhKatherine HeiglMeredith deals with her over protective stepmother, Cristina is caught between Burke and Marlow, and Derek fights to become Chief. Meanwhile, Alex continues the search for Jane Doe's identity, and Izzie's past comes back to haunt her.
- DirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglThe Chairman of Seattle Grace's board of directors is admitted, and the attendings vie for his favor, while the interns study for exams. Izzy and George are reminded of their infidelity, and Burke presses Cristina about wedding plans.
- 2005– 1hTV-146.9 (1.6K)TV EpisodeDirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglAddison heads for warmer climate to figure things out, Meredith's stepmother visits the clinic, Cristina's perfect wedding is challenged when she and Burke's mothers visit, and Izzie tries to talk to George.
- 2005– 1hTV-147.2 (1.4K)TV EpisodeDirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglAddison is pulled into the case of a high-risk surrogate mother, Meredith's stepmother develops a complication, Izzie struggles with George's decision, and Ava has surgery which may restore her memory.
- DirectorChristopher MisianoStarsEllen PompeoSandra OhKatherine HeiglThe interns face their first year medical exams. With the interns busy, the attendings must do their own legwork, Burke appoints a new best man, Cristina writes her vows, and Callie grows suspicious of George and Izzie.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe wedding day arrives. Richard chooses the new Chief and Chief Resident, the interns receive their exam results, Callie drops a bombshell on George while Izzie pours her heart out to him, and Burke makes an important decision.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe interns, now residents, deal with their own crops of interns. Callie struggles with her new position, and Burke makes a decision.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglLexie persists in trying to get to know Meredith, and Mama Burke descends once more.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglCallie hides in her office, frustrating Bailey who's itching to teach someone. Elsewhere, age becomes the theme as Izzie tries to convince 'Really Old Guy' he shouldn't die, Webber and Sloan set out to prove they're not too old to learn a new technique, and Karev is saddled with an intern who's past his prime.
- DirectorRandy ZiskStarsEllen PompeoSandra OhKatherine HeiglMeredith and her intern lose a patient after they give her the wrong diagnosis, Callie confronts Izzie, and McDreamy bonds with the other Grey.
- DirectorBethany RooneyStarsEllen PompeoSandra OhKatherine HeiglMeredith feels she's being haunted by her Mother's ashes, and Cristina is denied a surgery for a surprising reason.
- DirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglA man survives a parachute accident without serious injury, two women refuse treatment because of a wedding contest, and Cristina and Izzie jockey for inclusion in Hahn's surgeries.
- 2005– 1hTV-147.8 (1.2K)TV EpisodeDirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglHahn bans Cristina from her service, Bailey covers more and more of Torres' duties, and Izzie and George go to extreme lengths to recapture the magic of their first encounter.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglBailey crosses the line when the guy she had a crush on in high school shows up in the ER during an onslaught of high school students involved in a bus crash. The Grey sisters run and hide when their father shows up drunk, while Derek tries to get back into the dating scene with another doctor and Cristina tries her best to get back into Hahn's good graces.
- DirectorMichael GrossmanStarsEllen PompeoSandra OhKatherine HeiglAn accident in the ER bay leaves two paramedics fighting for their lives, and a third who refuses Bailey's care. Meanwhile, Alex juggles two women, and Lexie begins to bond with a patient.
- DirectorJessica YuStarsEllen PompeoSandra OhKatherine HeiglTragedy abounds for everyone at Seattle Grace as they all continue in efforts to get the paramedic out of the overturned ambulance, stop the bleeding of a man who won't quit, and a bigot with a Nazi tattoo on his stomach. On the personal side, Rebecca returns to spend time with Alex, Miranda's husband finds it harder to wait for her while she's in surgery, and Cristina still tries to get on Hahn's good side, even though Bailey has put her elsewhere.
- DirectorJohn TerleskyStarsEllen PompeoSandra OhKatherine HeiglBailey's son comes to the ER, Derek takes a housing step that puts pressure on Meredith, Izzie has a crisis of faith, and Cristina's choice may change her course with Hahn.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe judgment of the residents is skewed by a competition, Meredith tries therapy and a bear attack may be more than it appears.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglAddison is not prepared for all the changes that greet her upon her return to Seattle Grace for a specialized surgery, Meredith and Derek begin their clinical trial, Izzie feels left out, and Karev is confronted with an unexpected announcement.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglThe new clinical trial patient has a secret, Yang is dealt a blow from a distance by Burke, the nurses refuse to work with Sloan, and Meredith's therapist tells her some home truths.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglCristina is still in her slump and turning mean, Izzie finally confronts Ava/Rebecca, and Meredith's anger with her therapist is challenged by a patient with a Cinderella story.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglA surgical team battles the clock as they try to save a boy encased in cement, Karev's situation with an ever-disintegrating Ava brings back painful memories that interfere with his judgment, Derek and Meredith have one last chance at their clinical trial.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglMeredith and Derek are at odds over whether or not to continue with their 13th clinical trial patient and the doctors lift the final critical pieces of cement from the young boy's body. Meanwhile, Alex rushes Ava into the hospital and is forced to confront the reality of her condition.
- 2005– 1hTV-148.1 (1.4K)TV EpisodeDirectorRob CornMichael PressmanStarsEllen PompeoSandra OhKatherine HeiglMeredith and Derek find that "happily ever after" isn't as easy as they hoped, Cristina finds interest in a military doctor, and the Chief is surprised to hear that Seattle Grace is no longer ranked as a top-tier teaching hospital.