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- DirectorParis BarclayStarsHugh LaurieLisa EdelsteinOmar EppsHouse's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA very brave and mature 9-year-old girl has terminal cancer, but that is not what the problem seems to be.
- DirectorNelson McCormickStarsHugh LaurieLisa EdelsteinOmar EppsA girl crashes a Porsche after her boyfriend starts coughing up blood and continues to have unexplained bleeds. Clinic Cases: Cuddy gives House a month off clinic duties if he can spend a week off his pain meds.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsA couple risk their lives getting from Cuba to see House, but his preoccupation with staff issues may cost the woman her life.
- DirectorDavid ShoreStarsHugh LaurieLisa EdelsteinOmar EppsAn old patient of House comes back and seeks revenge upon him in the form of gunshot.
- DirectorElodie KeeneStarsHugh LaurieLisa EdelsteinOmar EppsHouse and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman who came into the clinic and proceeded to have a seizure.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsOn a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsHouse struggles to find out why a pianist savant is losing his ability to play. Ultimately, a decision must be made as to how much brain is necessary for a normal quality of life.
- DirectorJuan José CampanellaStarsHugh LaurieLisa EdelsteinOmar EppsStuck with clinic duty, House almost wishes he had the boring patients back after he encounters a young woman with an STD and the need to talk.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsWhen the son of a man in a vegetative state starts going into a coma, the vegetative man is reawakened chemically by House, who hopes to get some clues to the son's problems.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA patient whose relative has called in a favor with Cuddy presents with nonspecific minor symptoms that turn life-threatening, but House is distracted by a dream and an inability to urinate.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsA bus that House was riding crashes. House claims there's a victim on the bus who is dying, but not from the bus accident. He stops at nothing to figure out who the patient is and what is ailing him/her.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsThe team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsA person takes House, Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution, Thirteen makes decisions which leads her to think about her own condition.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsHouse is injured in a motorcycle accident. While recovering, he finds an accident victim suffering from a brain injury. House tries to prove the brain damage caused the accident, not vice versa, so he can treat the patient.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsHouse and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.
- DirectorKatie JacobsStarsHugh LaurieRobert Sean LeonardFranka PotenteHouse fights his doctors, the staff and his fellow patients when he's forced to stay in the psychiatric hospital under threat of permanently losing his medical license.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsAt therapy with Dr. Nolan, House tells about a cute amnesiac in ER, Wilson throwing him out and his old apartment being a mess after Alvarez broke in.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsCuddy, House and members of the team join forces with a search-and-rescue team to provide much-needed medical attention at the scene of an emergency.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsHouse entertains a school class on Career Day telling about his patient, a college student, who coughed up his lung. He spices up the story with quotes from movies. He later gets advice from 2 students outside principal's office.
- DirectorSanford BookstaverStarsHugh LaurieLisa EdelsteinOmar EppsCuddy dumped House. He moves into a luxury hotel and goes on a Vicodin, booze and cute hooker binge. The team gets a trampled rodeo bull rider but needs House to save him. Masters has a crush on their patient.