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- Meet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- Starting over isn't easy, especially for John Nolan who, after a life-altering incident, is pursuing his dream of joining the LAPD. As their oldest rookie, he's met with skepticism from those who see him as just a walking midlife crisis.
- Explores the high-pressure experiences of the first responders who are thrust into the most frightening, shocking, and heart-stopping situations.
- A father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- F.B.I. Special Agent Seeley Booth teams up with the Jeffersonian's top anthropologist, Dr. Temperance Brennan, to investigate cases where all that's left of the victims are their bones.
- Five friends with big egos and small brains are the proprietors of an Irish pub in Philadelphia.
- The continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- Axel Foley returns to Beverly Hills after his daughter's life's threatened. Includes old pals John Taggart and Billy Rosewood to uncover a conspiracy.
- The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- Lucifer Morningstar has decided he's had enough of being the dutiful servant in Hell and decides to spend some time on Earth to better understand humanity. He settles in Los Angeles - the City of Angels.
- A gifted young teen tries to survive life with his dimwitted, dysfunctional family.
- A suspended lawyer is forced to enroll in a community college with an eccentric staff and student body.
- The Philadelphia homicide squad's lone female detective finds her calling when she's assigned "cold cases," older crimes that have never been solved.
- The daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- The comical everyday life of whiny Mama's-boy sports columnist Ray Barone and his dysfunctional family: his long-suffering hard-working wife Debra, smothering mother Marie, coarse father Frank, and jealous policeman brother Robert.
- Al is the quintessential working class dad. Peggy, his wife, always wants more from him. With their children, they go through the highs and lows of ordinary life.
- A newly sober single mom tries to pull her life together in Napa Valley while dealing with her wayward mother.
- A group of friends living in Beverly Hills, California make their way through life from their school days into adulthood.
- A group of ambitious law students and their brilliant criminal defense professor become involved in a twisted murder plot that promises to change the course of their lives.
- The escapades of Stan Smith, a conservative C.I.A. Agent dealing with family life, and keeping America safe.
- Gay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- Welcome to the Montecito Resort and Casino in Las Vegas, where you can do anything you want, but Ed Deline and his crack surveillance team will be watching. Just remember: what happens in Vegas stays in Vegas.
- After being dumped by the girl he believes to be his soulmate, hopeless romantic Tom Hansen reflects on their relationship to try and figure out where things went wrong and how he can win her back.
- Detectives from NYPD's 15th Precinct investigate homicides within their precinct.
- When a suburban mother turns to dealing marijuana in order to maintain her privileged lifestyle after her husband dies, she finds out just how addicted her entire neighborhood already is.