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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- Follows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- A father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- After a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- While in his teens, Donny fathered a son, Todd, and raised him as a single parent until Todd's 18th birthday. Now Donny resurfaces just before Todd's wedding after years apart, sending the groom-to-be's world crashing down.
- A writer tries to juggle his career, his relationship with his daughter and his ex-girlfriend, as well as his appetite for beautiful women.
- Eleven love stories set in one of the most loved and hated cities of the world, New York City.
- A young Ob/Gyn doctor balances her personal and professional life, surrounded by quirky co-workers in a small office.
- When a girl attending a Christian high school becomes pregnant, all of her former friends turn on her and she is ostracized and demonized.
- When the first manned mission to Mars meets with a catastrophic and mysterious disaster after reporting an unidentified structure, a rescue mission is launched to investigate the tragedy and bring back any survivors.
- A nun, while comforting a convicted killer on death row, empathizes with both the killer and his victim's families.
- The Romans have created a country music dynasty, but when their reign as country royalty is put in jeopardy, Nicolette will stop at nothing to protect her family's legacy.
- "Entertainment Tonight" is the #1 syndicated entertainment newsmagazine in the world.
- Explores the emotional struggles and sexual politics of a group of doctors charged with healthy libidos. Their dedication to their personal lives is relentless, interrupted only by the occasional need to treat sick children.
- A womanizer helps his sister, his bar-owning roomie, and his three friends with much-needed dating advice.
- A weekday gabfest offering a female perspective on the day's headlines.
- A mother and daughter search for success in Beverly Hills.
- Lavinia and Suzette, former rock groupies and best friends, reconnect after twenty years; one is still as wild as ever, while the other has adopted a more conservative lifestyle.
- Three friends attend a school for fish submerged in a pet shop.
- Conan O'Brien, a Harvard Lampoon alumnus, hosts this late-night comedy/talk-show, which is often silly and whimsical.
- A conservative folk singer turns his hand to politics, running for the US Senate. He is not above dirty tricks and smear campaigns to gain an advantage over his opponent.
- Three nurses deal with patients and personal issues at Mercy Hospital.
- A woman's survivor's guilt from a Columbine-like event 15 years ago causes her present-day idyllic life to fall apart.
- Celebrities talk about paranormal experiences that they've had.
- A chronicle of Marilyn Monroe's family life and how she succeeded in hiding her most intimate secrets from the press and an invasive world.