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- Nick Hume is a mild-mannered executive with a perfect life, until one gruesome night he witnesses something that changes him forever. Transformed by grief, Hume eventually comes to the disturbing conclusion that no length is too great when protecting his family.
- Izzie becomes attracted to a male patient with a heart condition, and George treats Bex, an intersex patient. Meanwhile, Meredith's mother receives a visitor, and Derek and Addison's relationship is still rocky.
- The nurses are striking, and George refuses to cross the picket line. The interns are surprised by Bailey's seemingly immature replacement, Izzie connects with a pregnant girl, and an elderly woman's plight pushes Meredith to the limit.
- Christmas hits Seattle, with Izzie caring for a man who fell from his roof while hanging decorations. Meanwhile, Cristina helps perform a heart transplant on a depressed boy, and George has to contend with the family from Hell.
- A woman with a massive tumor is admitted, with all the surgeons required to scrub in. In their absence, Meredith is assigned a patient with Parkinson's and, because Alex's pager is not working, Izzie is left in charge of the floor herself.
- The lives of everyone in the OR are threatened when a patient enters with a bomb inside him, and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
- Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
- The mother of the quints blames herself. Meanwhile, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina takes care of an inmate desperate to stay at the hospital.
- Meredith must choose between her dog and her roommates. Meanwhile, George deals with an elderly patient who has outstayed her welcome, Bailey's pregnancy has complications, Alex gets his exam results, and Richard has a strike on his hands.
- Izzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
- While the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.
- Meredith and George face the consequences of their actions, Izzie gets closer to Denny, who has been readmitted, and Addison asks for Bailey's help with an embarrassing ailment.
- Derek and Addison are shaken by the arrival of a figure from their past. Meanwhile, Burke learns Cristina's secret, Izzie deals with a very unusual case, Meredith delves into her family's dirty laundry, and George pours his heart out.
- Cristina babysits for Bailey and does not take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, George connects with Callie, and Denny continues to come between Alex and Izzie.
- Superstition strikes, with the interns convinced a series of deaths will occur. A complication from the LVAD surgery puts Denny in the OR, Cristina plans to make George move out, and Richard's old AA sponsor is admitted for treatment.
- Cristina is desperate for George to move out of the apartment, while Izzie is jealous of Callie's relationship with him. Meanwhile, Cristina and Richard are rivals in a surgery seminar, and Meredith discovers a secret about her father.
- Meredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
- The victims of a serious car accident are admitted, with every surgeon required to help. Meanwhile, Callie's forwardness grates on Izzie, Addison makes Alex suffer, and Derek takes his frustration out on Meredith.
- The victims of a workplace shooting are admitted. Izzie puts her job on the line to ensure Denny gets a new heart, Callie makes an effort with Meredith, and Addison is suspicious of Derek.
- 2005– 1hTV-149.0 (1.9K)TV EpisodeBurke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.
- House tries radical procedures to save Foreman's life; Foreman's father visits.
- Richard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
- Guilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.
- Everyone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
- Izzie copes with her grief by baking furiously, and George has to deal with an obstinate patient. Meanwhile, Meredith must choose between Derek and Finn, Addison drowns her sorrows in alcohol, and Cristina meets Burke's difficult mother.
- Izzie returns to the hospital, but finds it difficult to go inside, and George is tired of Callie's presence at home. Meanwhile, Addison cannot seem to get rid of Mark, and Cristina tries to cope with caring for Burke.
- Izzie returns to the hospital under probation, and George tries to make amends with Callie. Meanwhile, Cristina's deletion of Bailey's name on Burke's OR board makes her assume he is against her, and Derek's irritating sister Nancy visits.
- Meredith becomes a patient, and Derek and Addison are equally angry at Richard for allowing Mark to join the staff. Meanwhile, Izzie receives a visit from Denny's father, and Burke is plagued by doubt over his ability to return to surgery.
- Derek, George, Alex, Burke, Richard, Joe and Walter go on a camping trip. Meanwhile, Meredith assists Mark with gender reassignment surgery, Izzie avoids discussing her grief, Addison works with Callie, and Cristina feels Bailey's wrath.
- George deals with his grief, Cristina and Burke continue to ignore each other, Addison avoids Alex, and Izzie decides to help Bailey with a project. Meanwhile, Richard makes a decision which sends all the attendings scrambling.
- The interns each react differently to a mass-casualty incident. Meanwhile, George crosses the professional line with Callie, Cristina asks Burke to keep quiet about their engagement, and Richard dons a new hairstyle.
- A toxic patient wreaks havoc. Meanwhile, Bailey opens the free clinic, but the lack of patients makes Izzie question her investment. Meredith's mother is admitted again, and Cristina makes Burke wait for an answer.
- A surgical team battles the clock as they try to save a boy encased in cement, Karev's situation with an ever-disintegrating Ava brings back painful memories that interfere with his judgment, Derek and Meredith have one last chance at their clinical trial.
- A magician's heart stops during a performance. At first House dismisses the case, but later changes his mind when complications arise. House has a contest to determine the next one to leave the team.
- A woman collapses at her wedding. She led a different life style before her marriage, House insists she hasn't changed. Wilson starts dating Amber.
- A bus that House was riding crashes. House claims there's a victim on the bus who is dying, but not from the bus accident. He stops at nothing to figure out who the patient is and what is ailing him/her.
- The team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.
- Edward is double crossed during a mission in Mexico while search of a Russian "new age" nuclear bomb. Back in Los Angeles, Ruthy is accidentally put into a dangerous situation by Edward, which causes an FBI agent to look into the matter, which comes dangerously close to discovering Tony's computer shop - and Mavis' secret Janus Organization. Elsewhere, Tom/Raymond's wife, Mary, tells Angie that she thinks there is more to the business trips Tom always takes, so she hires a private investigator to check it out. However, "Raymond" has other plans for the PI... and her.
- The drug trial brings back memories for Thirteen; Kutner and Taub scramble as they try to salvage a scam and save the team's patient whose gastric bypass may not have saved her life.
- A teenager collapses on stage, and the outcome will lead to a surprise for Cuddy. Wilson convinces House to be nice to his patients during the holidays. Foreman and Thirteen have issues when a trial patient drops from the program.
- House treats a priest who's lost his faith, issues an ultimatum to Foreman and Thirteen, and plays with Cuddy's desire to have him attend - or is it not attend? - her baby's naming ceremony.
- House's team resents being made complicit in a web of lies parents have told their son when he's brought in for treatment that may be related to his intersexuality. Meanwhile, no one's content that House is happy.
- The team tries to diagnose a condition that leaves the patient saying anything that he thinks, no matter whom it hurts, and Wilson raises House's antennae when he passes up a monster truck rally.
- House treats a patient who is convinced she's dying because of a death predicting cat. Meanwhile Taub catches up with an old High School classmate and contemplates leaving the team.
- Years after receiving body parts from an organ donor, five out of six recipients die within a few months, but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient, a young woman who received the donor's cornea, mysteriously dies as well. House retains a comical private investigator to investigate patients, doctors, and his estranged friend, Wilson.
- Taub treats a patient whose dying husband gets better as she becomes sicker, while the rest of the team deals with a devastating loss.