This show seems to have been aimed at a more conventional crowd than Cleese, Chapman and Palin's work with Monty Python. In fact, it has very, very little of the subversive and hilarious wit they displayed in that comedy troupe. The premise doesn't give much room for anything but Cleese portraying an intentionally annoying character (a noisy father disrupting his TV-watching children, an overly considerate date, a loud middle-aged woman in a movie theater) and noticeably bothering a character usually portrayed by Michael Palin. The characters don't have anything very funny about them, they are very straighforward and do nothing but annoy or get annoyed in the exact way you would expect based on Cleese's narrated set-up. There aren't any twists. There are very few moments when you get any hint of how brilliant these guys could be on their television shows and movies as Monty Python. In fact, it's kind of annoying seeing such talented men wasting away in such an unfunny piece of work - even if you're a Python fan, theres nothing really necessary about 'How To Irritate People', though the dedicated will inevitably check it out since theres almost always a copy by the Flying Circus videos at any rental store.
Review of How to Irritate People
