To protect Sam and Dean from a surprise attack from Raphael, Balthazar sends them both into an alternate universe where their lives are a TV show called Supernatural (2005).
Sam tries to move on without his brother and becomes hardened and more reckless in the way he hunts. Bobby and his psychic friend Pamela try to contact the other side to find out more about Dean's ultimate fate.
Dean hits an emotional rock bottom after a devastating personal loss. The Yellow Eyed Demon begins a calculated strategic move to unleash the armies of hell.
Amara unleashes a dark fog on a small town that causes everyone to go mad. Dean and Sam realize this is a stronger version of the original black vein virus Amara previously unleashed.