When the show flashes back to Jane Krakowski's character, Jacqueline, as a young girl, her hair perfectly matches the character of Cousin Vicki in National Lampoon's Vacation. Jane Krakowski made her movie debut as Cousin Vicki, in the original Vacation, when she was 15.
The scene where Lillian and Jacqueline beat up the school mascot was filmed down the street from Nyack High School, a school who's actual mascot was "The Nyack Indian" until 2020.
When Kimmy reads off the missed calls from Dong (Dong, Dong, Dong, Dong, Dong-Da-Dong, Dong, Dong) it is done to the tune of the song "Sweat" by Inner Circle.
The reverend says the apocalypse was to start June 6, 2006 at 6:66 pm. This is both a reference to the number of the beast in Rev 13:18 - 666.
The song Titus (Tituss Burgess) sings is the theme song from America's Funniest Home Videos.