(At ~ 0:19:15) MacDonald took the red pill, then immediately regurgitates his lunch. The gel cap did not have enough time to even start to dissolve.
When Det. Sykes is rushing to the cement factory in his police car he is clearly on a race track, and you can even see the red and white rumble strips on the corners.
As Det. Sykes is arriving at the warehouse, a head can be seen in the back seat of his vehicle.