Ashley Tisdale and Emily Osment have known each other before working together on the show. Both starred on Disney Channel sitcoms: Tisdale on The Suite Life of Zack & Cody and Osment on Hannah Montana. Ashley Tisdale also guest starred in the Hannah Montana episode "On The Road Again?".
Annie Potts filmed scenes for the pilot episode as Donna Kaminski (Josh's mother) but did not make it through the final cut, though you can still hear her voice in one of the scenes.
On February 6, 2018, series star Emily Osment announced that the series had been canceled and that the final ten episodes had been filmed.
Jonathan Sadowski and Jesse McCartney were also in Chernobyl Diaries together. They played brothers.
Jesse McCartney previously appeared in an episode of Hannah Montana as himself alongside Emily Osment.