It is the series with the highest budget and production values in the history of Greek television.
There were two entrances to Spinalonga, one being the lepers' entrance, a tunnel known as "Dante's Gate". This was so named because the patients did not know what was going to happen to them once they arrived. However, once on the island they received food, water, medical attention and social security payments. Previously, such amenities had been unavailable to Crete's leprosy patients, as they mostly lived in the area's caves, away from civilization.
In episode 22, Kiritsis says to Maria that placebo means 'to be liked'. However placebo means 'virtual medicine', so Kiritsis told that to impress Maria.
Stelios Mainas has also played Youlika's father in 'Mavra Mesanyhta' and later have collaborate in an episode of 'Ou fonefseis.