As House examines Georgia, she mentions having a crush on Ashton Kutcher. Kutcher and John Patrick Amedori, who plays Matt Davis in this episode, both played the character of Evan Treborn (albeit at different ages) in The Butterfly Effect (2004).
House and Chase argue over whether Chase is "British;" Hugh Laurie, who plays House, actually is British. Australia does in fact put the British Queen Elizabeth II on their money, as they are a Commonwealth member country.
Kurt Fuller and Shirley Knight appeared on Desperate Housewives together in the show's second season.