Since Dalmatian puppies grow so fast, each pup only got to "act" for two weeks before being replaced by a younger pup.
The film featured 55 "spot removal artists". In order to make the dalmatian without spots, "Oddball", completely white, the production team tried putting make-up on the dogs, trying to paint off the spots, putting plain white suits on the dogs, finding another breed of dog, none of this worked so eventually the spots had to be removed digitally, erased in each shot.
Many of the puppies found happy homes with many of the trainers. Most were returned to the breeders once they were too old to use for filming, and the breeders sold them off with special papers, noting that the puppy took a part in the filming of this movie.
Cruella's politically correct costume was made completely from black-and-white bubble wrap.