Although he died eleven years prior to this movie's release, Mel Blanc received credit for the voice of Baby Dino. The voice was re-used from The Flintstones (1960).
Harvey Korman (Colonel Slaghoople) was the original voice of The Great Gazoo on The Flintstones (1960).
The creators of the original animated series, William Hanna and Joseph Barbera, can be seen briefly during the wedding scene at the end of this movie. There's one quick shot of the two of them together singing along to the Flintstones theme song.
The producers opted for the prequel approach in this second movie mainly due to John Goodman's refusal to reprise his role as Fred Flintstone.
On the shelf in Betty O'Shale's (Jane Krakowski's) kitchen is a box of Post Fruity Pebbles, a real-life breakfast cereal derived from the original animated series.