The role of Cameron Poe was originally offered to Sylvester Stallone and Kurt Russell but both actors declined to appear in the film because both Stallone and Russell hated the script
The film is dedicated to Phil Swartz, an effects specialist who died during filming, when a rigged plane fell and crushed him. This is actually the second Jerry Bruckheimer production where there was a plane related death on set. Eleven years earlier, Art Scholl, a pilot/cameraman, died during filming of Top Gun (1986) when his camera plane failed to recover from a spin and plunged into the Pacific Ocean.
The Las Vegas scenes were filmed at the legendary Sands Hotel immediately prior to its demolition in late 1996. When the production team heard about the city's intentions to raze the historic landmark, they immediately scheduled a multiple camera setup to take advantage of the rare event, which is what you actually see in the movie.
The U.S. Marshals, who run the actual Con Air program, wanted nothing to do with this movie.