According to the series pilot, the character 'Six' was named because of the number of beers her parents drank the night of Six's conception. This detail was downplayed later in the series, referring to her birth order instead.
This was the last series Ted Wass acted in and the first he directed.
One notable guest star was David Schwimmer, who played Six's older boyfriend, Sonny, shortly before Schwimmer found success as Ross Geller on "Friends."
Although the show's original concept was for Blossom to have a hip, single musician dad, the executives insisted she has two parents in the pilot. However, after a great deal of fighting with show producers, the network caved, and the show went back to the original idea, casting Ted Wass as Blossom's single musician dad.
According to creator Don Reo, for the character of Blossom the network kept rejecting his possible casting choices because they wanted the typical Hollywood pretty girl with blonde hair and blue eyes. The network also didn't agree with any the casting choices for the dimwitted middle child except for Joey Lawrence, which the network wasn't too crazy about either. Reo claimed somebody during the casting process had expressed that Lawrence was "used up" because he was previously on the TV series Gimme a Break! a couple years earlier as a child actor.
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