The McDonald's scenes were all shot in City of Industry, CA, just outside Los Angeles. The set was a real-life McDonald's built specifically for crew member training and television commercials. Everything inside worked, but it never served a real customer. When it wasn't being used, it was locked up behind a chain link fence. It was torn down and rebuilt in 2006.
Whenever Paul Rudd appeared on Late Night with Conan O'Brien (1993), he would pretend to have brought a clip from his newest film, but he would always instead show the scene from Mac and Me of Eric rolling off a cliff and falling into the water. Rudd has done the joke for many years, even when promoting Ant-Man (2015). The first time he showed the clip, he was promoting Friends and promised to show a scene from the final episode; coincidentally Jennifer Aniston does have a small role in Mac and Me. In 2022 he was a guest on Conan O'Brien's podcast. As this was a strictly audio medium, Conan was caught totally by surprise when, after a long and involved story from Rudd about a non-existent project he claimed to be working on, he played the same Mac and Me clip.
Coca Cola and McDonalds backed the movie, thus the numerous references to both of those products.
When Steven Spielberg was once asked if he was ever tempted to take legal action against the filmmakers for copying the story of his beloved film E.T.- The Extraterrestrial (1982) he jokingly said he didn't want to get blamed for making anybody else watch it in order to make comparisons.
Jennifer Aniston: as an uncredited extra, sitting on a curb, watching the dancers in the McDonald's parking lot.
Nikki Cox: as an uncredited extra during the birthday party scene at McDonald's. She's a little redhead girl wearing a yellow shirt and white shorts.
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