In the documentary Amos 'n' Andy: Anatomy of a Controversy (1983), Alvin Childress (Amos) said that he never felt that the show was that negative of a portrayal of blacks since it was the only television show at the time that showed black people as businessmen, policemen, judges and doctors rather than maids or janitors.
After the show was canceled with 65 episodes, CBS wanted to syndicate the reruns but felt that they needed more shows. The cast was brought back to film an additional 13 episodes to premiere in syndication. These episodes were originally to be titled "The Adventures of Kingfish" but premiered with the "Amos 'n Andy" rerun package instead.
Redd Foxx (Fred Sanford) was a fan of this show. The series featured several cast members that would later appear on Sanford and Son. They include Lillian Randolph, Kim Hamilton, Ernest Mayhand, Bobby Johnson and Alvin Childress.
Episodes were shown to an audience whose reactions were recorded and edited into the show.
Sapphire's mother (Kingfish's mother-in-law) and Madame Queen were played by real-life sisters and veteran actresses Amanda Randolph and Lillian Randolph. The Randolphs played their same roles on the original radio show.