- Nephew of Anjelica Huston and Danny Huston.
- Grandson of John Huston.
- Unlike his famous paternal family, Jack Huston was born and raised in England, and naturally speaks with an English accent. On Jack's American father's side of the family, he is from Hollywood royalty, and on Jack's British mother's side, he is a descendant of aristocracy. Jack's paternal grandfather, John Huston, was of English, Scottish, Scots-Irish, distant German and very remote Portuguese ancestry, and Jack's paternal grandmother, ballerina and model Enrica (Soma), was of Italian descent.
- Son of Walter Anthony Tony Huston and Lady Margot Lavinia Cholmondeley.
- Jack and his girlfriend, Shannan Click, have a daughter, Sage Lavinia Huston, born in New York City, April 6, 2013, and a son, Cypress Night Huston, born in January 2016.
- Great-grandson of Walter Huston.
- Jack's maternal grandfather was Hugh Cholmondeley, 6th Marquess of Cholmondeley. Through the Marquess's father, George Cholmondeley, 5th Marquess of Cholmondeley, who was of English ancestry, Jack is a descendant of Robert Walpole, the first Prime Minister of England (in the 1700s). The 6th Marquess's mother, Jack's great-grandmother Sybil Sassoon, was from a Jewish family (from Iraq, India, Germany, and France), and through her, Jack is a descendant of both David Sassoon, the treasurer of Baghdad between 1817 and 1829, and Mayer Amschel Rothschild, who founded the Rothschild banking dynasty. Jack's maternal grandmother, Lavinia Margaret (Leslie), was of British background.
- He has dual U.K. and U.S. citizenship.
- Brother of Laura Huston and Matthew Huston.
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