- Became the voice of Stitch almost by accident. The character was originally intended to be silent, but when they decided for him to talk, Sanders recorded a few lines, and the filmmakers got so used to his voice that they cast him in the role.
- The movie Lilo & Stitch (2002) was based on an unpublished book he wrote in 1985.
- Toothless' appearance in How to Train Your Dragon (2010) was partially based on Stitch from Sanders and Dean DeBlois' earlier work Lilo & Stitch (2002), and the two movies follow a similar story.
- He has worked on two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically" significant: Beauty and the Beast (1991) and The Lion King (1994).
- His first live-action work as well as his first solo directorial effort was The Call of the Wild (2020).
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