- Is a natural redhead despite common misconception. Prepon stated in an interview that she dyed her hair black, for the role of "Alex Vause" in Orange Is the New Black (2013), to give her character the 'rockabilly look', but she is, in fact, naturally redheaded.
- Due to the seven inch height difference between her and co-star Mila Kunis on That '70s Show (1998), Laura and Mila were often filmed sitting down so that they could appear in the frame together. At other times, Mila wore platform shoes to give herself four extra inches.
- (June 3, 2018) Married her longtime boyfriend Ben Foster following nearly a 2-year-long engagement. They have 10-month-old daughter Ella together.
- Her last name is officially pronounced "PREE-pon".
- Used to be a ballet dancer.
- Returned to work a month after giving birth to her daughter in order to continue filming on Orange Is the New Black (2013).
- Close friends with her Orange Is the New Black (2013) co-stars, Taylor Schilling and Natasha Lyonne.
- Mother, with husband Ben Foster, of daughter Ella Foster (b. August 2017), and a son (b. February 2020).
- Her father was from a Russian Jewish family. Her mother has Irish, English, and German ancestry.
- She moved to Paris when she was 15 years old to do modeling.
- Began her YouTube channel on September 17, 2018 sharing new recipes and tutorials.
- Resides in Watchung, New Jersey, when not filming in Los Angeles.
- Hobbies include horseback riding, gymnastics, ice skating, ballet, tennis, and playing the piano.
- Hated the Catholic school girl uniform she had to wear during the fifth season of That '70s Show (1998).
- Her father was an orthopedic surgeon. Her mother is a high school teacher. One of her sisters is a lawyer.
- She is the youngest of 5 children. She has 3 sisters and 1 brother.
- In 2018, she became pregnant with her second child with husband Ben Foster. A sonogram at 16 weeks pregnant, showed that the baby has cystic hygroma which stopped brain and bones' growing. Doctors said that the pregnancy would not go to full term and Prepon was at risk carrying the baby any longer so she terminated the pregnancy.
- Said her favorite actor is probably Harrison Ford.
- Began a line of cooking products in 2021.
- Is proud of being a New Jersey native.
- Was a cheerleader in 8th grade.
- Was featured as #50 in Maxim Magazine's "Hot 100 of 2002" supplement. (2002)
- Ranked #84 in Stuff magazine's "102 Sexiest Women In The World" (2002)
- Named #77 on the Maxim magazine "Hot 100 of 2005" list.
- Has attended U.F.C. shows.
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