- Daughter of secretary Ann Brannack (1892-1955) and businessman George Skakel (1892-1955), both killed in an airplane crash in October 3, 1955.
- Has six siblings: Georgeann Skakel (1918-83), James Curtis Skakel (1921-98), George Skakel Jr. (1922-66), Rushton Skakel Sr. (1923-2003), Patricia Sistine Skakel (1925-2000) and Ann Skakel (b. 1933).
- Eleven children with Robert F. Kennedy: Kathleen Kennedy Townsend (b. 1951), Joseph Kennedy (b. 1952), Robert F. Kennedy Jr. (b. 1954), David (b. 1955), Courtney (b. 1956), Michael LeMoyne Kennedy (b. 1958), Kerry Kennedy (b. 1959), Christopher (b. 1963), Matthew (b. 1965), Douglas (b. 1967) and Rory Kennedy (b. 1968).
- Grandmother of Saoirse Kennedy-Hill and Joe Kennedy III.
- Daughter-in-law of Joseph P. Kennedy and Rose Kennedy.
- Younger sister of Rushton Skakel Sr.. Aunt of Tommy Skakel and Michael Skakel, Maria Shriver, Christopher Lawford, Caroline Kennedy, John Kennedy Jr..
- Ex-sister-in-law of Peter Lawford, Joan Bennett Kennedy.
- Ex-mother-in-law of Andrew Cuomo and Victoria Gifford Kennedy.
- Was pregnant with daughter Rory Kennedy when husband Robert F. Kennedy was assassinated.
- Awarded the Presidential Medal of Freedom by President Barack Obama on 24 November 2014.
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