- Was blacklisted in 1951 by the House Un-American Activities Committee (HUAC) for refusing to testify against her husband, blacklisted playwright/screenwriter Arnold Manoff. As a result, she got very little work for about 12 years.
- Reportedly declined the lead role that ultimately went to Bea Arthur on The Golden Girls (1985), because she didn't want to play a grandmother. Grant's daughter, Dinah Manoff, went on to co-star as Carol Weston in Empty Nest (1988), a direct spin-off of The Golden Girls (1985). Grant appeared as a guest star on the 4th season of the show in 1992, playing the title character in The Return of Aunt Susan (1992).
- Has three grandsons: Dashiell (b. 1997), Oliver (b. 2002), and Desi (b. 2002) via her daughter, actress Dinah Manoff, with whom Grant herself was three months pregnant when she completed her run of the Broadway play "A Hole in the Head".
- Finally came out with her real age in 2017, after decades of skimming years off her birthdate.
- As of 2022, she is the oldest surviving recipient of a Best Supporting Actress Oscar nomination, with Ann Blyth and Nancy Olson following close behind. She was nominated in 1952 for Detective Story (1951).
- On the August 3, 2014 broadcast of CBS News Sunday Morning with Jane Pauley (1979), Grant admitted to having had her first face lift at age 30.
- Has directed three Emmy Award-winning performances:Brenda Vaccaro in The Shape of Things (1973), Pearl Bailey in Cindy Eller: A Modern Fairy Tale (1985), Marlo Thomas in Nobody's Child (1986).
- Was the 76th actress to receive an Academy Award; she won the Best Supporting Actress Oscar for Shampoo (1975) at The 48th Annual Academy Awards (1976) on March 29, 1976.
- Revealed in 1978 that she had undergone an abortion early in her career.
- Daughter of Abraham (1896-1989), born in New York, and Witia (née Haskell) Rosenthal (1898-1980), born in Russia. Paternal granddaughter of Fishel (1866-1940) and Ida (née Palea) Rosenthal (1866-1949). Both were born in Russia and emigrated to America in 1892.
- She studied drama at HB Studio in Greenwich Village in New York City.
- According to her autobiography "I Said Yes to Everything", Grant lost her virginity at age 17 to an Irish dancer named Buster Burnell in August 1943.
- She and Joe Feury have been together since the mid-1960s. Despite her aversion to marriage after her divorce, they married so they could adopt Belinda, a two-year-old Thai child..
- Is one of 25 actresses to have won an Academy Award for their performance in a comedy; hers being for Shampoo (1975). The others, in chronological order, are: Claudette Colbert (It Happened One Night (1934)), Loretta Young (The Farmer's Daughter (1947)), Josephine Hull (Harvey (1950)), Judy Holliday (Born Yesterday (1950)), Audrey Hepburn (Roman Holiday (1953)), Goldie Hawn Glenda Jackson (A Touch of Class (1973)), Diane Keaton (Annie Hall (1977)), Maggie Smith (California Suite (1978)), Mary Steenburgen (Melvin and Howard (1980)), Jessica Lange (Tootsie (1982)), Anjelica Huston (Prizzi's Honor (1985)), Olympia Dukakis (Moonstruck (1987)), Cher (Moonstruck (1987)), Jessica Tandy (Driving Miss Daisy (1989)), Mercedes Ruehl (The Fisher King (1991)), Marisa Tomei (My Cousin Vinny (1992)), Dianne Wiest (Bullets Over Broadway (1994)) Mira Sorvino (Mighty Aphrodite (1995)), Frances McDormand (Fargo (1996)), Helen Hunt (As Good as It Gets (1997)), Gwyneth Paltrow (Shakespeare in Love (1998)), Judi Dench (Shakespeare in Love (1998)), Penélope Cruz (Vicky Cristina Barcelona (2008)), and Jennifer Lawrence (Silver Linings Playbook (2012)).
- Is one of 22 Oscar-winning actresses to have been born in the state of New York. The others are Alice Brady, Teresa Wright, Anne Revere, Celeste Holm, Claire Trevor, Judy Holliday, Shirley Booth, Susan Hayward, Patty Duke, Anne Bancroft, Barbra Streisand, Jane Fonda, Beatrice Straight, Whoopi Goldberg, Mercedes Ruehl, Marisa Tomei, Mira Sorvino, Susan Sarandon, Jennifer Connelly, Melissa Leo and Anne Hathaway.
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