- November 23rd, 2019: Johnny and then girlfriend Alaina Meyer welcomed their first child, a boy named Avery Orbison.
- Born in Belgium where his father was stationed while serving in the US Air Force. He moved to Chicago when he was 3 years old.
- Former smoker. He quit shortly before the eighth season of The Big Bang Theory (2007) began. He started smoking when he was only a teenager.
- Close friend of Sara Gilbert.
- At the age of 11, he received a Joseph Jefferson citation nomination for his critically-acclaimed performance as "John Henry" in "The Member of the Wedding".
- By age 7, he began performing in such prestigious theater productions as "Fiddler on the Roof", "Pippin" and "Galileo", opposite Brian Dennehy at The Goodman Theater in Chicago.
- In 1991, he starred in the made-for-TV movie Backfield in Motion (1991), which co-starred the production team of Roseanne Barr and Tom Arnold. The next year, Galecki joined the cast of Roseanne (1988) as Darlene's sensitive and put-upon boyfriend, David.
- Is 6 years, to the day, older than his The Big Bang Theory (2007) co-star, Kunal Nayyar.
- Used a pin to poke a hole through his ear lobe at the age of ten because his parents would not allow him to get his ear pierced professionally.
- Guest-starred on Blossom (1990) with Mayim Bialik, from The Big Bang Theory (2007), as her date in 1991. In 2011, their characters dated again in The Pulled Groin Extrapolation (2011) episode of The Big Bang Theory (2007).
- Star/producer/writer Roseanne Barr of Roseanne (1988) praises Galecki's "great vulnerability".
- His father was of Polish descent. His mother is of Irish and Italian ancestry.
- In 1989, only two Christmas movies were released by major studios in the US - National Lampoon's Christmas Vacation and Prancer. Johnny Galecki is the only person to star in both these films as Rusty Griswold and Billy Quinn respectively.
- Was considered for the role of John "Doc" Bradley in Flags of Our Fathers (2006).
- Older brother of Nick Galecki and Allison Galecki.
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