- Has a pacemaker.
- Is fluent in Italian.
- Says that, while she was at the tail end of filming her fake labor scene on Boston Legal (2004), she went into actual labor with her son Oliver.
- Graduated from Brown University in 1991 with a B.A. degree in Renaissance studies. She spent her junior year in Florence, Italy.
- Julie Benz is often mistaken for her and, when asked for her autograph, Benz would sign Bowen's name.
- Has three sons with her ex-husband Scott Phillips: Oliver McLanahan Phillips (b. April 10, 2007) and twins John Phillips and Gustav Phillips (b. May 8, 2009).
- Her ex-husband Scott Phillips, a real-estate investor, proposed Thanksgiving 2003, when she was starring as schoolteacher "Carol Vessey" on TV's Ed (2000). The two were married from September 2004 to September 2018.
- Her father Jack Luetkemeyer works in commercial real estate, Julie is the middle child among three daughters; older sister Molly Luetkemeyer is an interior designer in Los Angeles and younger sister Annie is a doctor in San Francisco.
- Commented that, apparently genuinely, the actor out there now that she finds the sexiest is DJ Qualls, who makes a very unconventional sex symbol.
- On her hit series Modern Family (2009) she was married to a real estate broker (played by Ty Burrell). In real life, she was married to a real estate investor.
- Finalized her divorce from Scott Phillips four days after their 14th wedding anniversary.
- Has said she regretted making The Last Man on Planet Earth (1999) because she was the non-lesbian character.
- She is a spokesperson for Neutrogena.
- Attended the prestigious Roland Park Country School in Baltimore, Maryland.
- Went to Costa Rica on her honeymoon. While there, she and her husband helped newly-hatched baby turtles crawl from their nest to the ocean, ensuring that the group survived instead of being attacked by predators.
- On the TV series Extreme (1995) she played a character named "Andie McDermot". She later co-starred in the movie An American Werewolf in Paris (1997), whose main male character (played by Tom Everett Scott) was named "Andy McDermot".
- She is of German, as well as Scots-Irish/Northern Irish, Welsh, English, Scottish, Irish, and French, descent. Her great-great-grandfather, John Valcoulon LeMoyne, was a U.S. Representative from Illinois, and her great-great-great-grandfather, Magnus Miller Murray, was Mayor of Pittsburgh, from 1828 to 1830, and from 1831 to 1832. Magnus's father was Commodore Alexander Murray.
- Lives in Beverly Hills, California.
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