- In an interview, he said he was constantly mistaken for being British because of his work on The Jeffersons (1975) as Harry Bentley.
- His acromeglia was diagnosed by an endocrinologist who saw Benedict in a play. He underwent treatment to stop the disease from advancing. He used his facial features to comic effect.
- Suffered from acromeglia as a young man, which accounted for his slightly over-sized nose and lower jaw.
- Had appeared on Maude (1972), All in the Family (1971) and The Jeffersons (1975) all within a two-week span.
- He began his acting career in the Theater Company of Boston, where his colleagues included then-unknowns Dustin Hoffman, Robert De Niro and Al Pacino.
- He was the youngest of six children. His father was a doctor, his mother a journalist.
- Attended and graduated from Boston College High School and Suffolk University in Boston, Massachusetts, where he grew up.
- He was awarded the 1988 Drama Logue Award for Outstanding Direction for "Frankie and Johnny in the Clair De Lune" at the Mark Taper Forum Theatre in Los Angeles, California.
- He was posthumously awarded the 2009 Elliot Norton Award by the Boston Theater Critics Association.
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