Jim Belushi, Jerry O'Connell, and Natalie Cohen in The Defenders (2010)

Jake Busey, Shannon Elizabeth, Jerry O'Connell, Jaime Pressly, and Horatio Sanz in Tomcats (2001)

River Phoenix, Corey Feldman, Wil Wheaton, and Jerry O'Connell in Stand by Me (1986)

Jerry O'Connell and Lauren Stamile in Midnight Bayou (2009)

Lara Flynn Boyle, Heather Graham, Jerry O'Connell, and John Corbett in Baby on Board (2009)

Kari Wuhrer, Jerry O'Connell, Cleavant Derricks, and Charlie O'Connell in Sliders (1995)

Jerry O'Connell and Megan Ward in Joe's Apartment (1996)

Sam Elliott, Susan Dey, and Jerry O'Connell in Blue River (1995)

Alyssa Milano, Jerry O'Connell, Ryan Reynolds, and Bridgette Wilson-Sampras in Buying the Cow (2002)

Jerry O'Connell and Rebecca Romijn in Love Locks (2017)

Jerry O'Connell, Sonja Morgan, Jeff Lewis, Luann de Lesseps, Teresa Giudice, Phaedra Parks, and Porsha Williams in WWHL 15th Anniversary Special (2024)

Jerry O'Connell in Mission to Mars (2000)

Jerry O'Connell and Margaret Josephs in Margaret Josephs & Jerry O'Connell (2023)

Jerry O'Connell and Rebecca Romijn in Rebecca Romijn & Jerry O'Connell (2022)

Jerry O'Connell and Mason Cook in Mockingbird Lane (2012)

Jerry O'Connell in Crossing Jordan (2001)

Jill Hennessy and Jerry O'Connell in Crossing Jordan (2001)

Jill Hennessy, Jerry O'Connell, and Alicia Coppola in Crossing Jordan (2001)

Jerry O'Connell and Jennifer Finnigan in Crossing Jordan (2001)

Jerry O'Connell and Steve Valentine in Crossing Jordan (2001)

Jerry O'Connell and Ken Howard in Crossing Jordan (2001)

Sabrina Lloyd, Jerry O'Connell, Cleavant Derricks, and John Rhys-Davies in Sliders (1995)

Jerry O'Connell and Christine Taylor in Room 6 (2006)