- Shared an Los Angeles house with Meg Ryan when both were struggling actresses.
- It was Mel Brooks who, after seeing what he considered such a great job in his Spaceballs (1987) film, personally recommended her for The Fly II (1989).
- (June 8, 2019) Married her boyfriend of 12 years Beau David Mleczko at Oleana Restaurant in Cambridge, Massachusetts. The couple, who were initially set up on a blind date 12 years ago, got engaged after a decade.
- When she isn't acting she works for such causes as cleaning up toxic waste and counseling high school kids against the dangers of drugs and alcohol.
- Her father is a philosophy professor and her mother is a Unitarian minister.
- Her father was from Guatemala. Her mother's ancestry is Polish and Finnish.
- In 2004, Zuniga suffered from mercury poisoning, which she attributed to overconsumption of fish. She said she had eaten sushi four times in the week prior to being taken to the emergency room and that her symptoms included weak memory, headaches, crying spells, skin rashes, and mild depression. After her diagnosis, Zuniga stopped consuming fish in addition to other meat.
- She has played the same character (Jo Reynolds) on three different series: Melrose Place (1992), Models Inc. (1994) and Melrose Place (2009).
- Graduated from Woodstock Union High School in Woodstock, Vermont in 1980.
- Appeared in the Bob Segar & The Silver Bullet Band's music video of their 180984 hit song, "Night Moves". In the first verse, the lyric refers to the girl in the black dress, "She was a black haired beauty with big dark eyes." Daphne Zuniga is the girl in the video who is sought after by the handsome young man in the pink shirt, who is played by actor a young Matt LeBlanc, of the hit series "Friends".
- Daphne was a founding board member of Earth Communications Office (ECO), an organization that harnesses the power of the environmental movement and the entertainment community. She is devoted to the conservation of our planet and "mercury awareness", having written articles for Oprah Winfrey's O magazine.
- She enjoys meditation and is a supporter of Spirit Rock Meditation Center in California, and Insight Meditation Society in Massachusetts.
- Older sister of Jennifer Zuniga.
- Sister of Rosario Zúñiga.
- She was a guest celebrity in the 1996 Endymion parade during Mardi Gras.
- Won an LA Weekly Award for best ensemble for Circus Theatricals production of Tartuffe.
- Played Princess Vespa in the movie Spaceballs.
- Co-hostess, with Lauren Hutton, of an infomercial for the "Lauren Hutton face disc" cosmetic. Also appearing is Beverly D'Angelo. (2006)
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