17 wins & 60 nominations
- 2020 Nominee Primetime Emmy
- Outstanding Comedy Series
Shared with: Liz Feldman · Will Ferrell · Adam McKay · Jessica Elbaum · Christie Smith · Linda Cardellini · Cara DiPaolo · Jessi Klein · Elizabeth Benjamin · Dan Dietz · Joe Hardesty · Buddy Enright · Denise Pleune - 2009 Nominee Primetime Emmy
- Outstanding Lead Actress in a Comedy Series
For playing: "Samantha Newly".
1998 Winner President Award- Star on the Horizon
- 2020 Nominee Golden Globe
- Best Performance by an Actress in a Television Series - Musical or Comedy
- 2009 Nominee Golden Globe
- Best Performance by an Actress in a Television Series - Comedy or Musical
- 2008 Nominee Golden Globe
- Best Performance by an Actress in a Television Series - Comedy or Musical
- 1999 Nominee Golden Globe
- Best Performance by an Actress in a Television Series - Comedy or Musical
- 2009 Winner People's Choice Award
- Favorite Female TV Star
- 1999 Winner People's Choice Award
- Favorite Female Performer in a New Television Series
- 2021 Nominee Actor
- Outstanding Performance by an Ensemble in a Comedy Series
Shared with: Linda Cardellini · Max Jenkins · James Marsden · Sam McCarthy · Natalie Morales · Diana Maria Riva · Luke Roessler
- 2012 Winner Humanitarian Award
- Norma Zarky Humanitarian Award
- 1989 Winner Young Artist Award
- Best Young Actress - Starring in a Television Comedy Series
- 1988 Nominee Young Artist Award
- Best Young Actress Starring in a New Television Comedy Series
- 1987 Winner Young Artist Award
- Exceptional Performance By a Young Actress in a New Television, Comedy or Drama Series
- 2002 Winner Young Hollywood Award
- "Something Extra" Award
- 2002 Winner Young Hollywood Award
- Brilliant Cut
- 2012 Winner Gracie
- Outstanding Female Actor in a Leading Role in a Comedy Series or Special
- 2008 Winner TV Land Award
- Siblings That Make You Grateful for Your Own Crazy Family
Shared with: David Faustino
- 2002 Winner Stinker Award
- Worst Song or Song Performance in a Film or its End Credits
"The Penis Song"Shared with: Cameron Diaz · Selma Blair
- 1993 Nominee Bravo Otto Germany
- Best Female TV Star (TV-Star w)
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