- Being very tall, Sutherland has long since had a habit of slouching over so he could meet other actors eye to eye.
- Prefers to shoot the opening scenes of a movie last in order to better set the tone of the movie to the audience.
- Had a near-death experience in 1979 when he was sick with meningitis. Doctors told him he had died for a time, and he claims to have had an out-of-body experience.
- Partook in the opening ceremony of the 2010 Olympic Winter Games in Vancouver as the voice-over narrator describing the history of Canada and was also one of the flag bearers of the Olympic flag.
- In the "making of" documentary for The Dirty Dozen (1967) Special Edition DVD, Sutherland says the was one of the "last dozen", meaning he was not going to have many lines. However when they were preparing to film the scene where Major Reisman (Lee Marvin) had to convince Colonel Breed (Robert Ryan) that a general was among them, it was supposed to be Posey (Clint Walker). However, Walker refused to do the scene so director Robert Aldrich picked Sutherland to do the scene. After that, Sutherland's role was expanded rather more. The Dirty Dozen (1967) is credited with helping Sutherland get more attention from filmmakers, thus launching his career. According to Sutherland, sometime later, Aldrich asked him to be in another movie but Sutherland declined. He says in the documentary that turning down Aldrich was one of his greatest regrets as an actor as he felt he owed Aldrich for helping to launch his career.
- Both Sutherland and Alan Alda, who took up the role of Hawkeye Pierce on M*A*S*H (1972) suffered from polio as children.
- He was so shocked by his own performance as the sadistic, perverse fascist leader in 1900 (1976), that he was unable to watch the film for years.
- Received his double major in Engineering and Drama from the University of Toronto. He had originally intended to become an engineer before trying acting.
- Two of his sons were named after directors he has worked with: Kiefer Sutherland was named after Warren Kiefer who directed Donald's first film The Castle of the Living Dead (1964), and his second son, Roeg Sutherland was named after Nicolas Roeg, who directed him in Don't Look Now (1973).
- Is a huge fan of the television series 24 (2001) starring his son Kiefer Sutherland as Jack Bauer and never missed an episode. However, he declined an offer to play Jack Bauer's estranged father, Phillip Bauer, who appeared in the series' sixth season, and the role instead went to James Cromwell.
- He and his son Kiefer Sutherland have both played artist Paul Gauguin.
- Has played together with his son Kiefer Sutherland in three movies: Max Dugan Returns (1983), Forsaken (2015), and A Time to Kill (1996) where they play enemies.
- Has appeared throughout M*A*S*H (1970) wearing glasses and a fishing bucket hat. This look was later mirrored by his son, Kiefer Sutherland, in Article 99 (1992).
- Between 1958 and 1960, he went to England and studied acting at the London Academy of Music and Dramatic Art (LAMDA).
- He was awarded the C.C. (Companion of the Order of Canada) on May 9, 2019 and Invested on: November 21, 2019 from the Canadian Governor General. He lives in Saint John, New Brunswick, Canada. The engraving on his honorary Academy Award reads: For a lifetime of indelible characters, rendered with unwavering truthfulness. He has been a Canadian presence worldwide for six decades, whose talent and magnetic charisma have made him a shining ambassador and promoter of Canada. This is a promotion within the Order.
- At age 14, his first part-time job was as a news correspondent for local radio station, CKBW.
- He was awarded a star on Canada's Walk of Fame in Toronto, Ontario in 2000.
- He replaced Richard Harris as the IRA terrorist Liam Devlin in The Eagle Has Landed (1976) after it was discovered that Harris had attended a fundraiser for the Provisional IRA in the United States.
- Originally wanted to be a sculptor, but decided to be an actor after witnessing people praise a drawing of Churchill that he thought was awful (he realized he could not make art to please other people). He had never attended a theater performance, and still had not when he received his first role. Thus he was behind the proscenium arch before ever having been in front of it.
- Grew up in the town of Bridgewater, Nova Scotia, where he also graduated from high school.
- Achieved cinematic fame in two completely different and contrasting war films. One was the cynical, edgy, sarcastic Korean War comedy M*A*S*H (1970), and the other was the gritty, action packed, violent World War II action film The Dirty Dozen (1967).
- Of Clan Sutherland.
- Has appeared in The Day of the Locust (1975) as a character named Homer Simpson, and then later made a guest appearance on The Simpsons (1989).
- Although several sources erroneously report that he and Francine Racette were married in 1974, Sutherland stated in a May 2000 "Daily Mail" article that they did not marry until August 1990. They met in 1974 and lived together for 16 years before getting married.
- He was an ardent fan of the Montreal Expos baseball team ever since it was founded. In the beginning of the 1983 season, when it looked like the team would finally be good enough to win the National League title, he ordered his agent not to accept any offers during the season, so that he could follow the team without distractions, even to the point of attending all of their games on their road trips. (The Expos failed to meet expectations and finished third).
- Was considered for the role of Dr. Hannibal Lecter in The Silence of the Lambs (1991).
- As of 2014, has appeared in three films that were nominated for the Best Picture Oscar: M*A*S*H (1970), Ordinary People (1980) and JFK (1991). Ordinary People (1980) won in the category.
- He and Kiefer Sutherland are both Emmy Award winners. He won in 1996 for Citizen X (1995), and ten years later, Kiefer won for 24 (2001).
- Has three sons with Francine Racette: Roeg Sutherland, born 1974; Rossif Sutherland, born 1978; and Angus Sutherland, born 1982.
- When polled by the American Film Institute, Sutherland chose Great Expectations (1946) as his favorite film.
- Twice, he has played a father grieving over a young son of his drowning: first, in Ordinary People (1980) second, in Forsaken (2015).
- Made two guest appearances on The Saint (1962), playing two different characters.
- Was awarded the OC (Officer of the Order of Canada) by the Governor-General of Canada on 18 December 1978 and the degree of Commander of the Order of the Arts and the Letters of France by the President of the Republic of France (unknown date 2012) for his services to Drama.
- His great-grandmother through male line was a third cousin of President Rutherford Birchard Hayes.
- Has rarely worked more than once with the same film director, which is something quite uncommon for an actor with a long career. The only exceptions he made (so far) are appearing in four films directed by Christian Duguay, two films by Nicolas Roeg, two films by Robert Towne, two films by Hugh Hudson and three films by Francis Lawrence.
- Has English, German and Scottish ancestry.
- Has dubbed (uncredited) the role taken by English actor William Devlin in The Shuttered Room (1967).
- He was awarded a Star on the Hollywood Walk of Fame at 7024 Hollywood Boulevard in Hollywood, California on January 26, 2011.
- Lives in Santa Monica, Los Angeles, Los Angeles County, California.
- Even though he receives top billing in The Day of the Locust (1975), he does not appear in the film for the first 42 minutes.
- He was originally cast as Franklyn Madson in Dead Again (1991), but was eventually replaced by Derek Jacobi.
- Was offered the role of Wyatt Earp in Doctor Who (1963): The Gunfighters but was not free so John Alderson took the role.
- Was a member of the "UC Follies" comedy troupe in Toronto, Ontario.
- In addition to an on-screen small role as a computer scientist in Billion Dollar Brain (1967), he also provided the mechanical voice for the eponymous "brain".
- Has starred on the television series Commander in Chief (2005) with Leslie Hope. During the first season of 24 (2001), Leslie Hope played the wife of his son, Kiefer Sutherland.
- Has two roles in common with Alan Alda. Sutherland played Flan in Six Degrees of Separation (1993), the role Alda played in an audio-book publication. Sutherland also played Hawkeye Pierce in M*A*S*H (1970), the role Alda played on M*A*S*H (1972).
- His son, Kiefer Sutherland, appeared in Stand by Me (1986), based on a short story by Stephen King. Donald later appeared in Salem's Lot (2004). Donald has himself appeared in two Michael Crichton adaptations: The Great Train Robbery (1978) and Disclosure (1994), while is other son Rossif Sutherland appears in Timeline (2003).
- Attended and graduated from Bridgewater High School in Bridgewater, Nova Scotia.
- He and Alan Alda both play Republicans with Presidential aspirations on television. Alda appears on The West Wing (1999), Sutherland appears on Commander in Chief (2005).
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