John Leguizamo, Ray Romano, Rick Pasqualone, James Patrick Stuart, and Chris Wedge in Ice Age: Dawn of the Dinosaurs (2009)

John Leguizamo, William H. Macy, Felicity Huffman, Mike Epps, Heather Lind, and Emory Cohen in Stealing Cars (2015)

John Leguizamo, Hayden Christensen, and Thandiwe Newton in Vanishing on 7th Street (2010)

John Leguizamo, Alfred Molina, Elizabeth Peña, Debra Messing, Freddy Rodríguez, Melonie Diaz, Luis Guzmán, Jay Hernandez, and Vanessa Ferlito in Nothing Like the Holidays (2008)

John Leguizamo and Bob Hoskins in Super Mario Bros. (1993)

John Leguizamo, Brittany Murphy, and Jason Schwartzman in Spun (2002)

John Leguizamo, Wesley Snipes, Natasha Lyonne, and Sam Jones III in Zig Zag (2002)

Mira Sorvino, John Leguizamo, Adrien Brody, and Jennifer Esposito in Summer of Sam (1999)

John Leguizamo, Wesley Snipes, and Patrick Swayze in To Wong Foo, Thanks for Everything! Julie Newmar (1995)

John Leguizamo and Barbie Ferreira in Bob Trevino Likes It (2024)

John Leguizamo and Patti LuPone in Patti LuPone & John Leguizamo (2023)

John Leguizamo, Toni Collette, and Auli'i Cravalho in The Power (2023)

John Leguizamo and Toni Collette in The Power (2023)

John Leguizamo, Eddie Murphy, and Reni Santoni in Doctor Dolittle (1998)

John Leguizamo, Janet McTeer, Nicholas Hoult, Judith Light, Hong Chau, Rob Yang, Aimee Carrero, Arturo Castro, Mark St. Cyr, and Anya Taylor-Joy in The Menu (2022)

Ralph Fiennes, John Leguizamo, Janet McTeer, Paul Adelstein, Reed Birney, Nicholas Hoult, Judith Light, Rob Yang, Aimee Carrero, Arturo Castro, Mark St. Cyr, and Anya Taylor-Joy in The Menu (2022)

Ralph Fiennes, John Leguizamo, Janet McTeer, Paul Adelstein, Reed Birney, Christina Brucato, Nicholas Hoult, Judith Light, Peter Grosz, Hong Chau, Rob Yang, Aimee Carrero, Arturo Castro, Mark St. Cyr, and Anya Taylor-Joy in The Menu (2022)

John Leguizamo and David Harbour in Violent Night (2022)

John Leguizamo, Adrien Brody, Ken Garito, Al Palagonia, and Michael Rispoli in Summer of Sam (1999)

John Leguizamo, Pedro Pascal, John Rosengrant, and Brendan Wayne in Chapter 9: The Marshal (2020)

John Leguizamo in When They See Us (2019)

Al Pacino and John Leguizamo in Carlito's Way (1993)

John Leguizamo and Stephen Colbert in The Late Show with Stephen Colbert (2015)

John Leguizamo and Leo Fitzpatrick in The Kill Point (2007)

John Leguizamo and Sissy Spacek in Bloodline (2015)

Mira Sorvino and John Leguizamo in Summer of Sam (1999)

Erika Eleniak, William Baldwin, John Leguizamo, and Sadie Frost in A Pyromaniac's Love Story (1995)

John Leguizamo, Jill Clayburgh, Anthony LaPaglia, Annabella Sciorra, and Jamey Sheridan in Whispers in the Dark (1992)

Ethan Hawke, Laurence Fishburne, John Leguizamo, Maria Bello, Drea de Matteo, and Ja Rule in Assault on Precinct 13 (2005)

John Leguizamo, Denise Richards, Anthony 'Treach' Criss, Fat Joe, and Peter Sarsgaard in Empire (2002)