Neil Patrick Harris and Chris Sarandon in Stark Raving Mad (1999)

Neil Patrick Harris and Constance Wu in Constance Wu/Neil Patrick Harris/Sheryl Crow (2019)

Neil Patrick Harris in A Series of Unfortunate Events (2017)

Neil Patrick Harris, Josh Radnor, Mieko Hillman, and Arielle Vandenberg in How I Met Your Mother (2005)

Neil Patrick Harris, Mieko Hillman, and Arielle Vandenberg in How I Met Your Mother (2005)

Neil Patrick Harris and Dave Franco in The Late Late Show with James Corden (2015)

Neil Patrick Harris and Lucy Punch in A Series of Unfortunate Events (2017)

Neil Patrick Harris, John DeSantis, Lucy Punch, Jacqueline Robbins, Joyce Robbins, and Usman Ally in A Series of Unfortunate Events (2017)

Neil Patrick Harris and Rosamund Pike in Gone Girl (2014)

Neil Patrick Harris, Alyson Hannigan, Jason Segel, Josh Radnor, and Cobie Smulders in Inside the Actors Studio (1994)

Neil Patrick Harris and Josh Radnor in How I Met Your Mother (2005)

Neil Patrick Harris and Ailsa Marshall in How I Met Your Mother (2005)

Neil Patrick Harris and Necar Zadegan in How I Met Your Mother (2005)

Neil Patrick Harris and Ella Thomas in How I Met Your Mother (2005)

Neil Patrick Harris, David Burtka, Roy Haylock, Haneefah Wood, Latrice Royale, and Ryan A. Taylor in Drag Me to Dinner (2023)

Neil Patrick Harris, David Burtka, Roy Haylock, Haneefah Wood, and Murray Hill in Drag Me to Dinner (2023)

Jennifer Lopez and Neil Patrick Harris in How I Met Your Mother (2005)

Neil Patrick Harris and Barbara Nitke in Uncoupled (2022)

Neil Patrick Harris and Tisha Campbell in Uncoupled (2022)

Neil Patrick Harris in The Unbearable Weight of Massive Talent (2022)

Neil Patrick Harris in The Matrix Resurrections (2021)

Neil Patrick Harris in Doogie Howser, M.D. (1989)

Neil Patrick Harris, Patrice Goodman, Justin Sanchez, Amadi Chapata, Josh Cruddas, and Isaac Arellanes in Ghostwriter (2019)

Neil Patrick Harris and Shameik Moore in What to Watch with Your Family (2020)

Neil Patrick Harris in Visible: Out on Television (2020)

Neil Patrick Harris, Alyson Hannigan, Jason Segel, Josh Radnor, and Cobie Smulders in How I Met Your Mother (2005)

Neil Patrick Harris, Jason Robards, and Eva Marie Saint in My Antonia (1995)

Neil Patrick Harris, Matthew Lillard, and Amanda Peet in Animal Room (1995)