- After she was rejected from her high school cheerleading squad, she joined the drama club and discovered that acting was her true passion.
- Turned down the role of Sarah Tobias in The Accused (1988). The part went to Jodie Foster who won her first Oscar for it.
- One of a handful of actors to work on two series at the same time: (Dynasty (1981) and T.J. Hooker (1982)).
- Entered an Arizona medical facility for diagnosis and treatment of her medication for anxiety and depression on June 24, 2008.
- On Sept. 25, 2017 (her 56th birthday), she was arrested at her home in Thousand Oaks, CA, on charges of felony domestic violence as well as battery on an officer. Her brother called police after arriving at her home and finding her arguing with her boyfriend. When police arrived, she allegedly became combative with them, and was arrested for assaulting an officer. She faces s felony domestic violence charge, as well as three counts of battery on emergency personnel, which are misdemeanors.
- Serves on the Board of Directors for the Motion Picture & Television Fund and supports The Michael J. Fox Foundation for Parkinson's Research.
- Best known by the public for her roles as Off. Stacy Sheridan on T.J. Hooker (1982), as Sammy Jo Carrington on Dynasty (1981) and as Amanda Woodward on Melrose Place (1992).
- On September 14, 2017, she was involved in a collision and transported to Los Robles Hospital & Medical Center in Thousand Oaks, CA. She went off the road and into a ditch at about 5:40 p.m. PST, a spokesman for the Thousand Oaks Police Department said. She was transported to the hospital with minor non-threatening injuries. Police could not say what caused the incident, but did say no drugs or alcohol were involved.
- Has been named three times on "People" magazine's Most Beautiful list.
- She is a distant cousin of Marla Maples Trump, on her father's side. Marla's maternal grandfather was a Locklear.
- Charged with a misdemeanor DUI in Santa Barbara County after her arrest in September for driving under the influence of prescription medicine [November 17, 2008].
- She is the daughter of Diane and William Locklear. Her ancestry includes English, Scottish and German. The surname Locklear often originates with families of Lumbee origin. Her paternal line can be traced back to her great-great-great-great-grandparents, Duncan Locklear and Nancy Quick, of South Carolina.
- Attended UCLA for a short period of time. She chose to pursue an acting career in lieu of the completion of her studies towards a bachelors degree. Her father, William Locklear, has served in various UCLA high-level administrative positions (Registrar, Director of the Office of Residential Life, etc.).
- Is a Republican.
- Engaged to Jack Wagner [August 14, 2011]. They called off their engagement [November 15, 2011].
- Her ex-husband, Richie Sambora, is a member of the rock band Bon Jovi.
- Her DUI case was dismissed after she pleaded guilty to reckless driving in a Santa Barbara (CA) court on January 2, 2009. She was not present in court.
- Starred in three highly successful Lifetime Channel original movies: Angels Fall (2007), Flirting with Forty (2008) and He Loves Me (2011). Flirting with Forty (2008) rated in the top three movies for the network. Angels Fall (2007)'s premiere, based on the best-selling novel by Nora Roberts, is ranked in the top ten of highest viewers in the history of the channel.
- Guest-starred in the episode, No Sniffing, No Wowing (2004), of former Spin City (1996) co-star Charlie Sheen's TV series, Two and a Half Men (2003).
- Is a fan of William Shatner's TV series Boston Legal (2004).
- On 4 October 1997 her daughter Ava Locklear (aka Ava Elizabeth Sambora), with ex-husband Richie Sambora, was born.
- Graduated from Newbury Park High School in Newbury Park, CA.
- Her daughter Ava Elizabeth has the same name as the daughter of Reese Witherspoon and Ryan Phillippe. Heather's daughter is nearly two years older than Reese's.
- Refused a regular part on the TV series Good Morning, Miami (2002). It was a role similar to the one she played on Spin City (1996). That role later went to Ashley Williams.
- Her acting coach was Tom Todoroff.
- Second Chance (1982) aired on her 21st birthday. It was also her debut episode. The Ransom (1985)(#5.1) aired on her 24th.
- Hospitalized in a Los Angeles hospital for treatment of a bacterial infection on December 1, 2010.
- Best friends with Jillian Barberie.
- Aunt of Shane Ahern.
- Represented by APA and Edelstein Laird.
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