George Clooney, John Turturro, and Tim Blake Nelson in O Brother, Where Art Thou? (2000)

George Clooney and Julia Roberts in Ticket to Paradise (2022)

George Clooney and Tye Sheridan in The Tender Bar (2021)

George Clooney and Alexa PenaVega in ER (1994)

George Clooney and Julianna Margulies in ER (1994)

George Clooney, Tricia Cast, Robert Knepper, and Devon Michael in ER (1994)

George Clooney and Devon Michael in ER (1994)

George Clooney and Caoilinn Springall in The Midnight Sky (2020)

George Clooney in The Midnight Sky (2020)

George Clooney and Clancy Brown in Hail, Caesar! (2016)

George Clooney and Greg Baldwin in Hail, Caesar! (2016)

George Clooney, Julianna Margulies, and Amy Ryan in ER (1994)

George Clooney, Julianna Margulies, Iyari Limon, and Amy Ryan in ER (1994)

George Clooney, Noah Wyle, and Abraham Benrubi in ER (1994)

George Clooney and Laura Dern in Grizzly II: Revenge (2020)

Brad Pitt and George Clooney in Wolfs (2024)

Brad Pitt, George Clooney, and Austin Abrams in Wolfs (2024)

George Clooney and Al Pacino in Ocean's Thirteen (2007)

Brad Pitt and George Clooney in Ocean's Eleven (2001)

George Clooney and Scott Jacoby in Return to Horror High (1987)

George Clooney in Return to Horror High (1987)

George Clooney and Lori Lethin in Return to Horror High (1987)

George Clooney and Michelle Pfeiffer in One Fine Day (1996)

George Clooney, Michelle Pfeiffer, Alex D. Linz, and Mae Whitman in One Fine Day (1996)

George Clooney and Quentin Tarantino in From Dusk Till Dawn (1996)

Brad Pitt, George Clooney, Matt Damon, Andy Garcia, Casey Affleck, Elliott Gould, Scott Caan, Bernie Mac, Carl Reiner, Eddie Jemison, and Shaobo Qin in Ocean's Eleven (2001)

George Clooney, Arnold Schwarzenegger, Alicia Silverstone, Uma Thurman, and Chris O'Donnell in Batman & Robin (1997)

Brad Pitt, George Clooney, Julia Roberts, Don Cheadle, Matt Damon, Andy Garcia, Catherine Zeta-Jones, Bernie Mac, and Jeffrey Wright in Ocean's Twelve (2004)

George Clooney and Diane Louise Salinger in Unbecoming Age (1992)

Brad Pitt, George Clooney, Don Cheadle, Matt Damon, Andy Garcia, Casey Affleck, Elliott Gould, Scott Caan, Bernie Mac, Carl Reiner, Eddie Jemison, and Shaobo Qin in Ocean's Thirteen (2007)