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- Two storm chasers on the brink of divorce must work together to create an advanced weather alert system by putting themselves in the cross-hairs of extremely violent tornadoes.
- The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- A computer specialist is sued for sexual harassment by a former lover turned boss who initiated the act forcefully, which threatens both his career and his personal life.
- A spaceship is discovered under three hundred years' worth of coral growth at the bottom of the ocean.
- The pilot for the popular TV series is set during 24 frantic hours in the lives of a group of doctors, nurses, and staff members of a busy emergency room at a Chicago hospital. They deal with the seemingly endless casualties that stumble into their place of employment. The central characters are the chief resident and family man Dr. Mark Greene, who is considering a job in private practice due to pressure from his demanding law student wife Jennifer; outgoing Dr. Doug Ross, who deals with cases in his own personal way; straight-arrow Dr. Susan Lewis, trying to get by another long 36-hour shift; inexperienced third-year med student John Carter; cocky surgical resident Dr. Peter Benton; and troubled chief nurse Carol Hathaway.
- Susan Lewis' boyfriend Div Cvetic, a psychiatric resident at County General, seems to be under a great deal of stress regularly lashing out at everyone. Doug Ross takes over for Mark Greene who takes a day off to be with his wife. He has a hard time keeping up with all the paperwork. John Carter is increasingly frustrated with Peter Benton who never seems to invite him to participate in surgeries. Benton learns the result of the fellowship he applied for and his mother shows up in the ER with a sprained ankle. Carol Hathaway treats a patient who was raped. A new ER aide, Bob, start work.
- Dr. David Morgenstern returns after a six-month absence recovering from his heart attack. His new outlook on life however has Kerry Weaver questioning his abilities. Elizabeth Corday decides to start a study on the use of artificial blood in the ER, but the only problem is that she fails to discuss it first with Rocket Romano. Doug Ross decides to apply for an ER attending position. Scott Anspaugh suffers a major relapse. Anna Del Amico is confronted by an irate husband who wants his ill wife to terminate her pregnancy. At the free clinic, Carol Hathaway has to deal with the case of an underage high school student who is sleeping with her 40-year-old teacher. Peter Benton hits a pedestrian with a car but Carter helps him out with an important piece of information.
- Abby comes close to breaking down trying to deal with her mother. Dr. Pratt goes for his required paramedic ride-along. Dr. Weaver confronts the man who stole her purse. Dr. Lewis has a teen admirer.
- At the hospital daycare, one of the child-care workers suggests to Peter Benton that he may want to have baby Reece's hearing checked. Doug Ross dodges a bullet by admitting upfront his error in detoxifying a baby without permission. Having been acting Chief for over 6 months, Kerry Weaver puts her name forward to replace David Morgenstern as Chief of Emergency Medicine only to be told she will have to compete for the job. The doctors treat a couple of Elvis impersonators who sky dive into Lake Michigan. When drugs go missing from the ER, John Carter suspects Anna Del Amico's ex-boyfriend.
- On a busy Halloween night, Carter and Abby are the only staffers in costume when victims of an apartment building fire pack the ER. Corday takes on a new med student for a surgical rotation - Paul Nathan, who suffers from Parkinson's disease and decided to pursue medicine after being diagnosed. Despite a difficult first day, both professionally and medically, Nathan makes a difficult diagnosis. Romano's rehab lags behind his expectations, and he begins to think his role in surgery is no longer an option. In a moment of personal weakness, he tries to express his feelings for Corday. Weaver continues to display erratic behavior, raising staff suspicions about her menopause. Luka's burgeoning sex addiction worsens, as an affair with Chuny is revealed, and tensions rise when he treats a patient with a perpetual erection.
- Dr. Pratt brings a gun into the ER; Dr. Weaver tries to conceal her pregnancy; a woman plots against her dying husband; Dr. Chen treats math students who overdosed on an unknown stimulant.
- Mark has to deal with the fact he can't see Rachel during the holidays and takes care of a Holocaust survivor whose grandchild is missing.
- An injured and condemned murderer wants to die in the ER rather than await execution; Abby advises a neighbor to seek shelter from her abusive husband.
- Dr. Weaver is in a difficult situation when an alderman tests positive for syphilis. Dr. Carter is impressed when he meets a man who runs an inner city clinic.
- Mark has to work for the fourth night in a row while a lot of the staff are absent and the number of patients is towering.
- Greene confronts Corday when she orders Rachel out of their home; Abby tries to protect a battered neighbor who refuses to press charges against her husband.
- The police question Drs. Pratt and Gallant about a rampage at the diner across from the ER. Dr. Lewis befriends her teen admirer, a cancer patient.
- As the new director of diversity, Benton studies medical school applications and discovers that his own academic record did not qualify him--he was admitted because of affirmative action. Weaver feels uncomfortable amongst Legaspi's lesbian friends. Carter treats an unvaccinated child who contracted measles.
- Carter greets the returning Kem, but their meeting with his father, Jack, gets tense after Carter announces plans for his grandmother's estate.
- Two boys brought in after a fight at school leads Cleo to discover that one of them has a number of bruises and infected wounds. Hathaway's obstetrics nurse, Abby Lockhart, joins the ER as a third year medical student on an ER rotation.
- Pratt and Weaver try to create a Christmas miracle when they work to save a girl wounded from gunfire. Eve gets into trouble after punching a disruptive patient. Also, Abby has a special gift for Luka.
- Carter and Lucy are discovered and the staff struggles to save them and go on with normal patient care.
- A soccer mom finds herself completely aware of everything going on around her, but is unable to move or speak after suffering a stroke.
- Doug treats dying Chia-Chia. Mark however feels he's not doing the right thing for Chia-Chia.
- Doug Ross' hopes of renewing his relationship with Carol Hathaway take a positive turn after the two of them kiss following a particularly stressful trauma, but his hopes are dashed when she decides to move in with boyfriend Tag. John Carter has a particularly good day when Dr. Green successfully walks him through a complex procedure. Haleh takes Dr. Benton to task when he refuses to act as a role model for a young gangbanger she has an interest in. Benton is also competing with Dr. Langworthy for a prestigious fellowship. It's Susan Lewis' birthday and her sister Chloe shows up at the ER drunk.
- Numerous mishaps threaten to mar Corday and Greene's wedding day. As the very pregnant Corday becomes increasingly agitated, the presence of her bickering divorced parents does little to improve her mood. With the intense rain, Greene has a difficult time making it to the church. But, evenutally, he arrives and they joyfully wed.
- Carol worries about her physics exam while Mark is heart-broken about Susan's departure and focuses solely on his job.
- Benton tries to save someone who, according to the other surgeons, can't be saved while the ER gets crammed with pregnant women.
- Sam's ex-husband shows up and wants to take Alex on a trip. Gallant is back and Neela hopes to see him before he goes back to Iraq.
- Kovac witnesses an accident and saves the young victim's life. Carter slowly recovers from his brutal attack and undergoes excruciating physical therapy. Hathaway helps two sexually active 14-year-old girls.
- Dr. Greene and Dr. Corday bond with their parents, Lucy cares for a patient with a psychotic break, and Valentine's Day celebrations in the ER end tragically.
- Benton is unable to find a job after Romano negatively influences local hospitals. He reluctantly agrees to accept Romano's demeaning offer of a per diem job at County with no benefits. Kovac and Abby are attacked by a mugger with a steel pipe. Injured, Kovac protects Abby and smashes the robber's head on the ground repeatedly.
- Abby helps a distraught boy whose mother died of a stroke; a man with schizophrenia, who once stabbed Carter and killed a doctor, is brought into the ER.
- The rainy night brings in diverse patients, including a mother involved in a car accident with her baby, a man with a satisfaction facilitator, and a comatose patient who suddenly wakes up. Also, Sam stands up to Eve and her strict ways and Jerry gets struck by lightning.
- Carter misses his pregnant girlfriend who has returned to Africa. A family of four is rushed to the emergency room after suffering carbon monoxide poisoning from their faulty furnace--forcing the claustrophobic Neela to accompany a newborn baby into an extremely uncomfortable hyperbaric chamber.
- Greene's daughter comes to live with him and Corday. Carter and Abby become more intimate. Chen must prove her skills while saving a baby. Weaver terminates Malucci after witnessing him having sex in an ambulance.
- Dr. Nate Lennox, a former professor with ALS, is brought in as the progression of his disease is chronicled through his own flashbacks as he is treated by each of the doctors at one point. As Lennox wants to give up, Abby fights to convince him to keep on fighting.
- When Dr. Lewis gets a hysterical call from her niece, Susie, she hurries to New York to search for the child and her sister Chloe.
- Benton takes a day off to help Carla. Carter finds out Edson falsified a chart.
- After Carter finds out Kem's mother is hospitalized in Paris he decides to go there to tell Kem how he feels about her. Meanwhile, Ray makes a fatal error.
- Another elderly rape victim is brought in. So is the rapist.
- Sam and Luka go on the search for her runaway son, Alex. Meanwhile, Pratt and Lewis guide Abby, Neela and Ray, who have become R2's, on how to teach the new interns.
- Dr. Carter, Abby and other staff of the ER are quarantined as the CDC investigate a mysterious, deadly outbreak.
- The realities of the ER may be too much for a child, but circumstances force Greene to bring his daughter Rachel with him on a day when the outdoor temperature tops 100 degrees and the air-conditioning doesn't work. Benton and Langworthy try in vain to save a boy shot in self-defense. Meanwhile, Lewis's broke sister, Chloe, steals Lewis's TV and VCR. After Ross crosses the line with Hathaway and Taglieri, Hathaway slugs Ross.
- Ross helps the mother of a dying boy; Benton attends a parent/child signing class. Corday doesn't give her account in the case against Dr. Romano. Romano blackmails Corday into dropping her support for Doyle's harassment lawsuit against Romano, but Kerry gets Romano to rewrite his insulting and inaccurate review of Doyle's job performance. The ER unites to help an injured woman who needs to find temporary homes for her many dogs as she gets treatment. Mark treats the hospital janitor, Mobalage, whose injuries suggest he has been tortured in the past. Carter discovers something with one of the med students he is mentoring.
- An accidental overdose brings Drs. Green and Corday's baby into the ER.