Also, although I love Laurie's performance, it could get annoying if it was just a one-man show (again: "LAO: CI"), and Shore has wisely surrounded him with a large cast of characters to make things more interesting. Each character adds something to the show, and it's very entertaining to see all the different personalities bouncing off each other (and ultimately, bouncing off House). My one complaint is that character development has been a little slow (especially with Chase), and if they don't branch out in that area, things could get stale.
Finally, I've heard some people criticize this show for being too unrealistic, but all I can say to that is, it's not supposed to be (what mystery show is!?). Yeah, the diseases patients come in with are totally off-the-wall, and House diagnoses and cures them in unrealistic ways, but if they were coming in with commonplace diseases, they'd get cured in 5 minutes and there wouldn't be a show! If you can manage to suspend your disbelief and think of it as a character-based mystery show (and can handle some of the graphic surgery scenes), you're bound to enjoy it.