To try and describe it is something like attempting to nail Jell-O to the wall. There's no plot, really; but there are a lot of things going on, threads of peoples' lives, loosely connected. The film describes itself as being "about a bunch of people in Virgil, Texas" and it is, but actually it's about the wonderful absurdity, lunacy even, of "normal" American life. David Byrne's Narrator character isn't condescending or snide. He's innocent, wondering, matter-of-fact. He looks at the cookie-cutter tract houses and asks, "Who can say it isn't beautiful?"
This is a very unique little movie, and people either seem to get it, or not. I can never predict who will or won't catch the humor. But, if you're not smiling by the end of the intro sequence, this probably isn't the movie for you. Personally, I was laughing my butt off by then. I can't say that this movie made me a better person, but it did add something to my world and gave me a great appreciation for the mind of David Byrne.