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| Credited cast, sorted by IMDb STARmeter: | |||
| Luke Evans | ... | Bill Simmons | |
| Evangeline Lilly | ... | Claire Reimann | |
| Armie Hammer | ... | Jake Kahane | |
| Gary Oldman | ... | Dr. Tyrone Brower | |
| Mia Kirshner | |||
| Michelle Rodriguez | ... | Supervisor Garrett | |
| Sam Worthington | |||
| Indira Varma | ... | Madira Brower | |
| Greg Kinnear | ... | Dean Geoff Talbot | |
| Martin Donovan | ... | Lawrence Morgan | |
| Lily-Rose Depp | ... | Emmie Kelly | |
| Michael Aronov | ... | Minas | |
| Toni Garrn | ... | Sarah | |
| Kid Cudi | ... | Ben Walker | |
| Veronica Ferres | ... | Meg Holmes | |
Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.
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