Lucifer Morningstar has decided he's had enough of being the dutiful servant in Hell and decides to spend some time on Earth to better understand humanity. He settles in Los Angeles - the City of Angels.
An invisible and mysterious force field descends upon a small actual town of Chester's Mill, Maine, USA, trapping residents inside, cut off from the rest of civilization. The trapped townspeople must discover the secrets and purpose of the "dome" or "sphere" and its origins, while coming to learn more than they ever knew about each other and animals too.
A skeptical female clinical psychologist joins a priest-in-training and a blue-collar contractor as they investigate supposed miracles, demonic possession, and other extraordinary occurrences to see if there's a scientific explanation or if something truly supernatural is at work.
When ten people wake up on a treacherous island with no memory of who they are or how they got there, they set off on a trek to try to get back home. They soon discover this world is not as it seems. Faced with the island's extreme psychological and physical challenges, they must rise to their better selves -- or die as their worst ones.