The series is to be set 20 years after the events of Star Trek: Nemesis (2002) (which was set in the year 2379), in the year 2399. Using the TNG-based Stardate format, this would place the start of the series just after Stardate 76000.
Star Trek: Nemesis (2002) was the last time that Sir Patrick Stewart played Captain Jean-Luc Picard in a live-action production. However, he did reprise the role in several video games and animated comedy series.
This will be the first Star Trek television series since Star Trek: The Next Generation (1987) to be titled something other than the main location featured in the series (Deep Space Nine, Voyager, Enterprise, and Discovery).
Patrick Stewart last played Picard, for what was then believed to be the final time, in Star Trek: Nemesis (2002), which premiered two years after his debut as Professor Xavier in X-Men (2000). Likewise, his final turn as Xavier in Logan (2017) came two years before his return as Picard in this series.
This will be the first time TNG's Jean-Luc Picard and Voyager's Seven of Nine have appeared together onscreen. The two of them are the only known beings to have ever been fully assimilated into the Borg Collective, and then successfully rescued and restored to their original species.