Post college graduation, JP and Leah have moved to opposite coasts from their hometown of Cincinnati, Ohio. Their third blind mouse, Colleen, is reluctantly entering her last year of college, after taking a year off to even out her mental state. Before leaving town, JP, Leah, and Colleen have their own graduation ceremony of sorts and stumble upon a Santeria alter. Not knowing the power that these kinds of ritualistic tokens hold, they decide to touch the various items in the altar, thus transferring unwanted negative energy to themselves. After a psychic in New York tells JP that he cursed himself, and Leah's mother tells Leah that her grandfather has died, both JP and Leah return to Cincinnati. They grab Colleen and explain that they must sacrifice to the gods to undo the curse. 'Cursed' takes place in Cincinnati, Ohio, Los Angeles, and New York City and tells the story of how these three millennials have inadvertently cursed themselves.