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| Episode cast overview, first billed only: | |||
| Rachel Brosnahan | ... | Miriam 'Midge' Maisel | |
| Alex Borstein | ... | Susie Myerson | |
| Michael Zegen | ... | Joel Maisel | |
| Marin Hinkle | ... | Rose Weissman | |
| Kevin Pollak | ... | Moishe Maisel (voice) | |
| Tony Shalhoub | ... | Abe Weissman | |
| Luke Kirby | ... | Lenny Bruce | |
| Caroline Aaron | ... | Shirley Maisel | |
| Joel Johnstone | ... | Archie Cleary | |
| Brian Tarantina | ... | Jackie | |
| John Scurti | ... | Nicky | |
| Erik Palladino | ... | Frank | |
| Regina Hoyles | ... | Enid | |
| Colby Minifie | ... | Ginger | |
| Megan McGinnis | ... | Loula | |
In the Season Two premiere, Midge takes the stage for a foreign audience, while Abe and Rose find themselves in a new world. Susie experiences the repercussions of having a bad reputation in the business, as Joel regroups after quitting his job.
Atrocious comeback!First 33min were an astonishing waste of precious time! Nothing but stand up comedy! Please! Such high hopes! Quite the failure!