The Sforza duke having been murdered on Pazzi orders, Jacopo plots to hire condottiere count Montesecco to seize Firenze and eradicate the Medici. Lorenzo still hopes for peace trough pope Sixtus IV, but as he sends his sister, she's prevented from speaking the Medici man in the curia, whom Montesecco blackmails into abusing her to set the trap. It now appears that a papal teen nephew just create Cardinal Riario is heading a papal peace mission, but is serves as cover for the bloody plot to slay all Medici in the cathedral. However a delay occurs. Giuliano and Boticelli are shattered, and on hostile terms, blaming each-other for the death from consumption of their unavailable beloved Simonetta in her husband Vespucci's home dungeon.