The main actress, real transgender woman Daniela Vega, was hired as a script consultant. Even though she had no prior experience as an actress, after some time working with her, director Sebastián Lelio offered the lead role, which she accepted.
Daniela Vega wasn't initially supposed to play the leading role in A Fantastic Woman (2017) and was approached by director Sebastián Lelio as a consultant on the research he was carrying on about the transgender Chilean community. As Daniela began to share her personal experiences with him, Lelio decided to entrust her with the role.
Daniela Vega became the first openly transgender person to ever present at the Oscars when she introduced Sufjan Stevens's performance of "Mystery of Love" from Call Me by Your Name (2017) (Dolby Theatre Los Angeles / 4 March 2018).