A large portion of season 1 takes place in Baltimore, Maryland: the same city that was famously the backdrop for the acclaimed HBO series The Wire. (Which also starred Wendell Pierce as Detective Bunk Moreland)
Unlike most previous installments in the Jack Ryan film series, the show is not based on any of Tom Clancy's novels. Krasinski described the plot as a "ripped from the headlines" story based on current geopolitics.
During a conversation between Greer and Ryan about getting access to a mobile (cell) phone, Greer mentions trying a loved ones birthday or anniversary. An almost verbatim conversation takes place between Dan Murray, Ryan and Petey when they are trying to access a password protected account in Tom Clancy's Clear and Present Danger (1994).
As a measure of authenticity for the action sequences, executive co-producer Michael Bay connected the production team with Military Technical Advisor Kevin Kent who had earlier advised Bay for productions such as The Last Ship (2014) and his "Transformers" series of films, etc.
The trivia items below may give away important plot points.
In the last episode, Greer gets transferred to Moscow as station Chief and as Jack is offered Greer's former position. In the "read book" that Greer left to Jack, the note says "Booked you a flight to Moscow". This may be an allusion to the first and most famous Jack Ryan novel "The Hunt for Red October" which was also the first Jack Ryan movie, starring Alec Baldwin as Jack. The plot is about a Russian nuclear ballistic missile submarine that has gone rogue between Russia and the US.
When members of the terrorist cell are handling the radioactive material, they imported it into the US at the Port of Baltimore. In the film version of Tom Clancy's The Sum of All Fears (2002), the vending machine hiding the nuclear bomb was also imported into the Port of Baltimore.