No. This is supposedly going to be sequel to the original two Ghostbusters films. Furthermore, the trailer (Paul Rudd) says "There hasn't been a ghost sighting in 30 years", implying the events occurring in the 2016 movie, never happened.
According to a Vanity Fair article, "Rick Moranis, who has limited his screen work in recent years, is not expected to reprise his role."
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